The severity and distribution of tau pathology distinguish corticobasal degeneration and progressive supranuclear palsy
Objective: To elucidate whether the severity and distribution of tau pathology reflect the clinical presentations in progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). Background:…Can we stage tau pathology in PSP?
Objective: To evaluate distribution pattern of tau pathology in different PSP clinical subtypes and develop a staging system. Background: Progressive supranuclear palsy (PSP) is a…18kDa Translocator Protein PET in 4-Repeat Tauopathies – A Cross-Sectional Single Center Study
Objective: The aim of this single center study was to analyse the potential of 18F-GE-180 TSPO PET as a biomarker in 4R-tauopathies. Background: The pathological…Comparative Grey and White Matter Tau Pathology in LBD and PSP using Digital Histologic Measurements
Objective: To compare the regional distribution of cortical tau pathology between Lewy body disorders (LBD: Parkinson’s disease and dementia with Lewy bodies (DLB)) and progressive…Drug Utilization in a Real World Cohort with Progressive Supranuclear Palsy
Objective: To evaluate the frequency of prescription medications commonly associated with the management of PSP in the community. Background: Progressive Supranuclear Palsy (PSP) is a…Skin in the game: Small fiber neuropathy in Parkinson’s disease and atypical parkinsonisms.
Objective: The aim of our study was to compare somatic and autonomic small fiber density, through skin biopsy, in Parkinson's disease (PD) and atypical parkinsonisms…Deciphering Corticobasal Syndrome: are clinical features and FDG-PET imaging capable of predicting amiloyd status?
Objective: The present study aimed at establishing clinical and brain functional patterns at FDG-PET that could distinguish Corticobasal Syndrome(CBS) variants due to AD from Tau pathology based on Pittsburgh Compound…Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3β signaling pathways
Objective: To investigate the role and mechanism of C3a receptor in okadaic acid（OA） induced SH-SY5Y cells tau hyperphosphorylation model Background: Neurofibrillary tangles aggregated from hyperphosphorylated…Heavy metals implicated in a geographical cluster of progressive supranuclear palsy induce tau accumulation and apoptotic cell death in cultured neurons
Objective: To test the hypothesis that certain metals may cause cellular damage suggesting tauopathy. This is an early step in testing the hypothesis that environmental…Cortical and subcortical atrophy in typical and variant Parkinson-plus syndromes: PROSPECT-M-UK study
Objective: To investigate grey matter volume in typical and variant Parkinson-plus syndromes, to correlate these with disease severity, and to assess regional atrophy within disease…
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