Session Information
Date: Monday, June 20, 2016
Session Title: Surgical therapy: Parkinson's disease
Session Time: 12:30pm-2:00pm
Location: Exhibit Hall located in Hall B, Level 2
Objective: The aim of the study was to evaluate the effect of intraoperative microelectrode recording in patients with deep brain stimulation of the subthalamic nucleus on the main symptoms in Parkinson’s disease.
Background: The effect was evaluated in a three-year prospective non-randomized trial. The study involved 60 patients treated with STN-DBS. Microelectrode recording was performed for 30 patients (MER+) and was not performed for the other 30 patients (MER-); 28 patients with PD receiving conservative treatment formed the control group (mean age 54.5 years, mean disease duration 9.7 years). Patients were evaluated under "OFF" and "ON"- medication conditions before treatment and at 6, 12 and 24 months from the start of the study.
Methods: The following standard scales were used: Parkinson’s disease Quality of Life-39 Scoring System, Unified Parkinson’s disease Rating Scale – UPDRS, Hoehn and Yahr scale, Schwab and England scale, Tinetti Balance and Mobility Scale – TBMS, Mini-Mental State Examination – MMSE, Montreal Cognitive Assesment – MoCA, State-Trait Anxiety Inventory – STAI, the total equivalent dose of levodopa -LEED.
Results: There was a significant decrease in the severity of the "OFF" – medication condition and improvement of the motor function in all patients with DBS STN compared with the control group over the whole observation period. In the control group the severity of the disease was much greater and had a tendency to deteriorate over time. However, there was no significant difference between MER+ and MER- groups. Neurodynamic function in the MER+ group improved slightly, while neurodynamic criteria showed a decline in MER- patients in the first year, which reached nearly the preoperative or even a little lower level after three years of observation (-4.2%). Neurodynamic criteria in the control group were decreasing progressively and were equal to -7.1% compared to -9.4% in MER- and + 7.4% in MER+ patients after three years of observation. A significant reduction of LEED was noted in both MER groups. It increased slightly by the third year, but still did not reach the baseline. In the control group the increase of LEED progressed and reached + 59.1% vs. -52.9% for MER +, and -58.3% in MER- patients.
To cite this abstract in AMA style:
N. Gubareva, E. Bril, A. Tomskiy, N. Fedorova, S. Asriyants. Efficiency of intraoperative microelectrode recording in patients with deep brain stimulation of the subthalamic nucleus. Three-year comparative research [abstract]. Mov Disord. 2016; 31 (suppl 2). https://www.mdsabstracts.org/abstract/efficiency-of-intraoperative-microelectrode-recording-in-patients-with-deep-brain-stimulation-of-the-subthalamic-nucleus-three-year-comparative-research/. Accessed December 11, 2024.« Back to 2016 International Congress
MDS Abstracts - https://www.mdsabstracts.org/abstract/efficiency-of-intraoperative-microelectrode-recording-in-patients-with-deep-brain-stimulation-of-the-subthalamic-nucleus-three-year-comparative-research/