Prediction of amyloid positivity in Dementia with Lewy bodies using the early-phase 18F-FP-CIT PET images
Objective: This study aims to explore whether early-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) positron emission tomography (PET) images can predict β-amyloid positivity on 18F-florbetaben (18F-FBB) PET scans…Prospective Study of Gait and Multimodal MRI Biomarkers for Multiple System Atrophy
Objective: We aimed to develop new multimodal biomarkers allowing objective monitoring of early MSA progression to improve outcome definition for future neuroprotective trials. Background: MSA…Movement disorders in Brain Sagging Syndrome- A Systematic Review
Objective: Objective: This study aims to systematically review the array of movement disorders observed in patients diagnosed with brain sagging syndrome (BSS) secondary to spontaneous…Combining alpha-synuclein PET and seeded amplification assays to improve the diagnostic accuracy of Multiple System Atrophy of the Parkinsonian subtype (MSA-P)
Objective: To determine whether the combination of spatial (PET [18F]ACI-12589) and conformational (skin seed amplification assay; SAA) a-syn data aids the early differential diagnosis of…Pharmacokinetics And Safety Of YA-101, A Dual Inhibitors Of D-Amino Acid Oxidase (DAAO) And NLRP3 Inflammasome, In Healthy Subjects: A Double-Blind, Placebo-Controlled, Randomized, Single Dose and Multiple Dose Phase I Study
Objective: To evaluate the safety, tolerability, and pharmacokinetics (PK) profile of YA-101 in healthy volunteers with single dose and multiple dose Background: Multiple System Atrophy…Explore cellular heterogeneities of orbitofrontal cortex in multiple system atrophy using spatial transcriptomics
Objective: To explore the spatial organization and cellular complexity of the orbitofrontal cortex (OFC) in multiple system atrophy (MSA) via spatial transcriptomic (SRT). Background: The…Seed Amplification Assay for the differentiation of αSyn seed subtypes
Objective: To identify soluble αSyn-seed types present in brain homogenate (BH) and CSF using αSyn seed amplification assay (synSAA) Background: Lewy bodies and neurites are…Increasing diagnostic accuracy of Multiple System Atrophy – A Videolibrary on clinical and imaging features
Objective: To provide short, high-quality videos and MRI images presenting typical MSA features to supplement new MDS-MSA criteria1. Background: The MDS criteria for the diagnosis…Rapid Cognitive Deterioration and Related Factors in Progressive Supranuclear Palsy: a One-Year Follow-up Study
Objective: Based on a relatively large cohort, we aimed to show the switch of cognitive status in patients with progressive supranuclear palsy (PSP) after one-year follow-up…Altered activity of lysosomal hydrolases in monocyte-derived macrophages as potential biomarker for differential diagnosis of multiple system atrophy
Objective: The aim was to assess the possibility of differentiating synucleinopathies (Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA) by lysosomal…
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