STN-DBS Frequency Effects in Parkinson’s: An fMRI Study
Objective: The study aimed to investigate the impact of deep brain stimulation (DBS) at varying frequencies on brain activation patterns during a motor (force-tracking [FT])…Bioreactor-produced iPSCs-derived Dopaminergic Neuron-containing Neural Microtissues Innervate and Restore Motor Function in a Dose-dependent Manner in a Parkinson Rat Model
Objective: To demonstrate the efficacy of a ready-to-graft 3D neural microtissue product – manufactured at large scale – as a therapeutically viable option to treat Parkinson’s…Early changes in the locus coeruleus in mild cognitive impairment with Lewy bodies
Objective: To evaluate NMS signal changes in the locus coeruleus (LC) in mild cognitive impairment with Lewy bodies (MCI-LB) as compared to healthy controls (HC)…Development and Feasibility Trial of iSupport-PD, a Digital intervention for carers of people with Parkinson’s and Cognitive Impairment
Objective: Develop a digital intervention to prevent or decrease the mental and physical health problems associated with caring and improve quality of life of carers…Clinical and neuroimaging factors associated with survival in Multiple System Atrophy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Multiple System Atrophy (MSA)…Identification of Brain Atrophy Subtypes in Prodromal and Overt Synucleinopathies: A Multicenter Study
Objective: To identify unique subtypes of synucleinopathy with distinct spatiotemporal patterns and trajectories of brain atrophy and disease burden. Background: The synucleinopathies manifest as a…From Images to Insights: Subtyping Parkinson’s Disease Using Unsupervised Learning on MRI Data
Objective: To explore the heterogeneity of Parkinson's disease (PD) using unsupervised clustering of neuroimaging data, aiming to identify distinct subtypes based on volumetric features. Background:…Minimally Clinical Important Differences of Hemifacial Spasm Score-30 (HFS-30) and Hemifacial Spasm Score-7 (HFS-7) for Patients with Hemifacial spasm
Objective: We aimed to estimate the MCIDs of HFS-30 and HFS-7, and factors associated with the MCID along with baseline and change score of HFS-30…A 3D CNN Approach for the Classification of Multiple System Atrophy using Multimodal Multicentric MRI
Objective: To automatically distinguish between healthy controls (HC) and patients with multiple system atrophy (MSA) with a completely automatic approach using a 3D convolutional neural…First in vivo evidence of the role of the noradrenergic system in olfactory dysfunction in Parkinson’s disease
Objective: To investigate the relationship between in vivo noradrenergic markers and olfactory impairment in patients with Parkinson’s disease (PD). Background: Degeneration of the noradrenergic (NA)…
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