String Vessel Formation Regionally Increases in Long Duration Parkinson’s Disease
Objective: Parkinson's disease is a movement disorder characterised by α-synuclein deposition in the form of Lewy bodies and Lewy neurites. Vascular changes have been thought to contribute…Quantitative Assessment of X-linked Dystonia-Parkinsonism Using Wearable Sensing Technology
Objective: To create a quantitative, objective framework for assessing combined dystonia parkinsonism using kinematic data from wearable sensors combined with machine learning (ML), enabling clinician-independent…Clinical Utility of Synuclein Skin Biopsy in the Initial Diagnosis and Evaluation of Parkinsonian Disorders
Objective: To determine the clinical utility of phosphorylated alpha-synuclein (P-SYN) within skin biopsies in diagnostic and management decisions. Background: The initial diagnosis of Parkinson’s Disease…Multifaceted Challenges in Multisystem Atrophy Management: Medication Sensitivity, Emotional Lability, and Increased Fall Risk
Objective: Multisystem atrophy (MSA) epitomizes a formidable quandary within neurological and geriatric disciplines, delineated by complex manifestations encompassing autonomic dysfunction, parkinsonism, and cerebellar ataxia. This…New onset movement disorders following COVID-19 infection
Objective: To determine the prevalence and phenotype of movement disorders following SARS-CoV-2 infection in hospitalised individuals. Background: Although movement disorders, including parkinsonism, following SARS-CoV-2 (COVID-19)…Hydrocephalic Progressive Supranuclear Palsy: An Underrecognized Entity
Objective: We describe a case of NPH-like presentation of PSP, review literature surrounding this entity, and discuss key diagnostic considerations and implications. Background: Despite advances…Vestibular impairment, turning direction and turn progression in Parkinson’s disease
Objective: To explore the correlation between the Romberg test condition 4 and turn progression in most affected and least affected body side directions in people…Association between Antiepileptic Drugs and Parkinson’s Disease: A Strong or Weak Link?
Objective: To perform a meta-analysis to show the association between different Antiepileptic Drugs(AEDs) and Parkinson’s disease(PD). Background: PD is a neurodegenerative disorder affecting 1-2% of…α-Synuclein Pathology Across Movement Disorders and Neurodegenerative Diseases by Seed Amplification Assay
Objective: To assess the frequency of pathological α-synuclein (αSyn) in various movement disorders and neurodegenerative diseases from a specialized movement disorder clinic by αSyn seed…TOPAS-MSA: Targeting Oligomer Pathology of Alpha-Synuclein – A Study Evaluating the Safety and Efficacy of Emrusolmin in Patients with Multiple System Atrophy
Objective: The objective of the TOPAS-MSA study is to assess the safety and efficacy of emrusolmin (anle138b/TEV-56286), an orally bioavailable small molecule targeting aggregated α-synuclein,…
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