Two parallel nigrostriatal subcircuits mediate the arousal effect of dopaminergic neurons in substantia nigra pars compacta
Objective: This study systematically investigates the involvement of dopaminergic (DA) neurons in substantia nigra pars compacta (SNc) in wakefulness-sleep regulation and explores the underlying circuit…Comparative Effectiveness of Behavioral or Drug Therapy for Overactive Bladder Symptoms in Parkinson Disease
Objective: Assess the comparative effectiveness of behavioral or solifenacin drug therapy over 12 weeks for overactive bladder (OAB) symptoms according to the International Consultation on…Implementation of the Parkinson’s Disease-Health Index (PD-HI), a Novel, Validated, Disease-Specific Patient-Reported Outcome Measure, in a 24-Month Natural History Study
Objective: To evaluate and optimize the relevance, usability and longitudinal responsiveness of the Parkinson’s Disease-Health Index (PD-HI) for use in PD clinical trials. Background: The…Clinical and neuroimaging factors associated with survival in Multiple System Atrophy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Multiple System Atrophy (MSA)…Intensive Neurophysiological Rehabilitation System As a New Approach for Treatment of ASD Children
Objective: Rehabilitation of ASD children is the issue of the day as it's attributed to constantly increasing quantity of autistic children. Background: Existing rehabilitation approaches…Evaluation of Effectiveness of Medical Nutrition Therapy Services for Individuals with Parkinson’s Disease: A Quality Improvement Initiative
Objective: To assess the type of dietetic consultation services used in a Parkinson Disease Center of Excellence (PDCE) for individuals with Parkinson’s disease (PD). 2.To…The Freezing of Gait Change of Direction (FOG-COD) Test: A Novel Measure to Predict Falls
Objective: To examine the relationship between freezing of gait (FOG), falls history, and a novel clinical measure in persons with parkinsonism. Background: Freezing of gait…Depressive Symptomatology and Neuropsychiatric Profile in Patients with Idiopathic Parkinson’s Disease without Dementia (IPDWD). Preliminary Data from a New Scale Specifically for Measuring Depression in Patients with IPDWD.
Objective: : To identify whether depression in patients with IPDWD correlates with different types of behavioral symptoms. Background: Depression is considered a frequent neuropsychiatric pathology…PreActive-PD Telehealth Coaching to Increase Physical Activity in Early-Stage Parkinson Disease: A Randomized Controlled Feasibility Trial
Objective: To assess the feasibility/acceptability, and preliminary efficacy of Pre-Active PD intervention delivered via telehealth to increase physical activity (PA) engagement in people with early-stage…Dermal 4R-Tau seeding as a novel biomarker for Progressive Supranuclear Palsy
Objective: To ascertain the presence of misfolded tau species in the skin of Progressive Supranuclear Palsy (PSP) patients and evaluate its utility as a potential…
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