A Phase 2 Study of ATH434 a Novel Inhibitor of α-Synuclein Aggregation for the Treatment of Multiple System Atrophy
Objective: Describe baseline fluid and neuroimaging biomarker data of an early MSA study population Background: MSA is a rapidly progressive neurodegenerative disorder characterized by aggregated…Peripheral inflammation severity in differential diagnosis of progressive supranuclear palsy and multiple system atrophy – usefulness of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and neutrophil-to-high-density lipoprotein-cholesterol ratio
Objective: Assessment of the possible differences in peripheral inflammation severity between progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) with the use of three…Identification of underlying Lewy body pathology in primary tauopathies by α-synuclein seed amplification assay
Objective: To determine intravitam prevalence of α-synuclein (αSyn) pathology in primary tauopathies, such as PSP and CBS, by αSyn seed amplification assay (synSAA) Background: Neuropathological…Syllable-based speech characteristics as potential biomarker for differential diagnosis of Parkinson’s disease, multiple system atrophy, and cerebellar ataxia
Objective: To analyze syllable-based speech characteristics in patients with Parkinson’s disease (PD), multiple system atrophy (MSA), and cerebellar ataxia (CA) to determine if there is…TOPAS-MSA: Targeting Oligomer Pathology of Alpha-Synuclein – A Study Evaluating the Safety and Efficacy of Emrusolmin in Patients with Multiple System Atrophy
Objective: The objective of the TOPAS-MSA study is to assess the safety and efficacy of emrusolmin (anle138b/TEV-56286), an orally bioavailable small molecule targeting aggregated α-synuclein,…Legmain/Asparaginyl endopeptidase-resistant tau fibril fold produces corticobasal degeneration-specific C-terminal tau fragment
Objective: This study monitored the formation of CBD (corticobasal degeneration)-type fibrils that exhibit astrocytic plaques, a characteristic CBD pathology, using Legumain-cleavage site-specific antibodies and CBD-specific…Tau Deposition in Locus Coeruleus is Associated with Rapid Eye Movement Sleep Behavior Disorder in Progressive Supranuclear Palsy.
Objective: In this study, we aimed to investigate the frequency of Rapid eye movement sleep behavior disorder (RBD) occurring in a large cohort of PSP,…Clinical and neuroimaging factors associated with survival in Progressive Supranuclear Palsy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Progressive Supranuclear Palsy (PSP)…Development and Validation of a Clinical Scale for Distinguishing Multiple System Atrophy from 4-Repeat Tauopathies
Objective: We aimed to develop a clinical scale that distinguishes between Multiple System Atrophy (MSA) and 4-repeat tauopathies (4RT: CBD, PSP) using a standardized neurological…α-Synuclein Seed Amplification Assay Amplification Parameters and Progression in Parkinson’s Disease
Objective: To examine the relationship between the reaction parameters of the cerebrospinal fluid (CSF) αSyn seed amplification assay (αSyn-SAA) to the risk of developing motor…
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