Long term real-world monitoring supports the superiority of adaptive deep brain stimulation: preliminary data on three patients with Parkinson’s disease
Objective: Describe the preliminary results of adaptive deep brain stimulation (aDBS) treatment for Parkinson’s disease (PD) and the value of real-world monitoring in defining clinical…The Benefits of Whole-Body Electro Muscle Stimulation (WB-EMS) in a patient with Parkinson’s Disease
Objective: To determine the motor and non-motor benefits of WB-EMS in a patient with Parkinson’s disease Background: Parkinson’s disease causes both motor and non-motor symptoms.…Targeting inflammation and autophagy: a dual-inhibition strategy to reduce α-synuclein pathology in GBA1-associated Parkinson’s disease
Objective: To assess the effects of combined inhibition of mTOR (autophagy regulator) and STING (inflammation regulator) on α-synuclein phosphorylation, tyrosine hydroxylase expression, and lysosphingolipid levels in…Harnessing Digital Biomarkers to Monitor Early Parkinson’s Disease Progression
Objective: This study aimed to identify gait metrics capable of capturing disease progression in individuals with early Parkinson’s disease (PD). Background: Digital gait assessments have…Efficacy and Safety of Transcutaneous Auricular Vagal Stimulation on Gait in Patients with Parkinson’s Disease: a Systematic Review
Objective: To perform a systematic review on the efficacy and safety of Transcutaneous auricular vagal stimulation on gait in patients with Parkinson’s disease. Background: PD…LRRK2 Pathway Inhibition By NEU-411, a Potent, Selective, CNS-Penetrant LRRK2 Inhibitor In Healthy Participants
Objective: The aim of this work was to evaluate LRRK2 pathway modulation by the potent, selective, CNS-penetrant LRRK2 inhibitor NEU-411 in healthy adults and elderly…Changes in Motor States Throughout the Waking Day With Tavapadon in People With Parkinson’s Disease
Objective: To evaluate motor states throughout the waking day when adding tavapadon to oral carbidopa/levodopa in adults with Parkinson’s disease experiencing motor fluctuations. Background: Long-term…The MJFF PRKN/PINK1 Project
Objective: To i) establish an expert consortium on PRKN/PINK1-linked Parkinson’s disease (PD), ii) improve our understanding of genotype-phenotype relationships and disease mechanisms, and iii) establish…Who is lost? Monitoring recruitment in the EJS ACT-PD trial to improve understanding of inclusive recruitment
Objective: To improve equitable access to participation in the EJS ACT-PD trial (Edmond J Safra Accelerating Clinical Trials in Parkinson’s Disease) Background: A minority of…Impact of Allogeneic Mesenchymal Stem Cells in Motor and Non-Motor Symptoms of Parkinson’s Disease: A Phase 2 Randomized Trial
Objective: To assess the efficacy of repeated intravenous (IV) allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) infusions in reducing motor and non-motor symptoms in people…
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