MDS Abstracts

Abstracts from the International Congress of Parkinson’s and Movement Disorders.

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  • 2025 International Congress

    Long term real-world monitoring supports the superiority of adaptive deep brain stimulation: preliminary data on three patients with Parkinson’s disease

    L. Caffi, R. Habib, L. Borellini, E. Mailland, F. Cogiamanian, M. Arlotti, L. Rossi, S. Bonvegna, C. Palmisano, S. Marceglia, A. Priori, G. Pezzoli, M. Locatelli, IU. Isaias (Würzburg, Germany)

    Objective: Describe the preliminary results of adaptive deep brain stimulation (aDBS) treatment for Parkinson’s disease (PD) and the value of real-world monitoring in defining clinical…
  • 2025 International Congress

    The Benefits of Whole-Body Electro Muscle Stimulation (WB-EMS) in a patient with Parkinson’s Disease

    N. Duff, C. Cawood, M. Noble (Parktown, South Africa)

    Objective: To determine the motor and non-motor benefits of WB-EMS in a patient with Parkinson’s disease Background: Parkinson’s disease causes both motor and non-motor symptoms.…
  • 2025 International Congress

    Targeting inflammation and autophagy: a dual-inhibition strategy to reduce α-synuclein pathology in GBA1-associated Parkinson’s disease

    T. Usenko, A. Bezrukova, K. Basharova, E. Zakharova, S. Pchelina (Gatchina, Russian Federation)

    Objective: To assess the effects of combined inhibition of mTOR (autophagy regulator) and STING (inflammation regulator) on α-synuclein phosphorylation, tyrosine hydroxylase expression, and lysosphingolipid levels in…
  • 2025 International Congress

    Harnessing Digital Biomarkers to Monitor Early Parkinson’s Disease Progression

    V. Shah, C. Silva-Batista, D. Engel, A. Ragothaman, P. Burgos, P. Carlson-Kuhta, F. Horak, M. Mancini (Philadelphia, USA)

    Objective: This study aimed to identify gait metrics capable of capturing disease progression in individuals with early Parkinson’s disease (PD). Background: Digital gait assessments have…
  • 2025 International Congress

    Efficacy and Safety of Transcutaneous Auricular Vagal Stimulation on Gait in Patients with Parkinson’s Disease: a Systematic Review

    K. Silva, L. Cabral, M. Kozlowski, W. Damasio (São José dos Campos, Brazil)

    Objective: To perform a systematic review on the efficacy and safety of Transcutaneous auricular vagal stimulation on gait in patients with Parkinson’s disease. Background: PD…
  • 2025 International Congress

    LRRK2 Pathway Inhibition By NEU-411, a Potent, Selective, CNS-Penetrant LRRK2 Inhibitor In Healthy Participants

    C. Wong, S. Dheerendra, T. Dang, F. Nahab, J. Zheng, S. Savage, Z. Pei, C. Wynne, S. Jackson, L. Desnoyers (South San Francisco, USA)

    Objective: The aim of this work was to evaluate LRRK2 pathway modulation by the potent, selective, CNS-penetrant LRRK2 inhibitor NEU-411 in healthy adults and elderly…
  • 2025 International Congress

    Changes in Motor States Throughout the Waking Day With Tavapadon in People With Parkinson’s Disease

    R. Hauser, R. Pahwa, L. Harmer, A. Lind (Tampa, USA)

    Objective: To evaluate motor states throughout the waking day when adding tavapadon to oral carbidopa/levodopa in adults with Parkinson’s disease experiencing motor fluctuations. Background: Long-term…
  • 2025 International Congress

    The MJFF PRKN/PINK1 Project

    E-J. Vollstedt, A. Balck, AN. Basak, M. Brand, N. Brüggemann, J-C. Corvol, S. Ertan, M. Funayama, M. Gagliardi, N. Hattori, C-H. Lin, K. Lohmann, P. Mir, D. Narendra, G. Saranza, L. Stefanis, A-H. Tan, EM. Valente, S. Padmanabhan, K. Brockmann, C. Klein (Luebeck, Germany)

    Objective: To i) establish an expert consortium on PRKN/PINK1-linked Parkinson’s disease (PD), ii) improve our understanding of genotype-phenotype relationships and disease mechanisms, and iii) establish…
  • 2025 International Congress

    Who is lost? Monitoring recruitment in the EJS ACT-PD trial to improve understanding of inclusive recruitment

    M-L. Zeissler, R. Davidson, K. Hockey, G. Mills, R. Petty, C. Pugh, T. Liddle, Y. Yiannakou, T. Foltynie, C. Carroll (Newcastle upon Tyne, United Kingdom)

    Objective: To improve equitable access to participation in the EJS ACT-PD trial (Edmond J Safra Accelerating Clinical Trials in Parkinson’s Disease) Background: A minority of…
  • 2025 International Congress

    Impact of Allogeneic Mesenchymal Stem Cells in Motor and Non-Motor Symptoms of Parkinson’s Disease: A Phase 2 Randomized Trial

    M. Schiess, J. Martinez-Lemus, T. Thomas, E. Tharp, C. Onuigbo, J. Suescun, T. Ellmore, T. Le, E. Rodarte-Rascon, R. Ritter Iii, C. Green (Houston, USA)

    Objective: To assess the efficacy of repeated intravenous (IV) allogeneic bone marrow-derived mesenchymal stem cell (allo-hMSC) infusions in reducing motor and non-motor symptoms in people…
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