Exploring Clinical and Neurophysiologic Predictors of Adaptive Deep Brain Stimulation Response in Parkinson’s disease
Objective: To evaluate clinical and neurophysiologic characteristics that may predict a positive clinical response to adaptive deep brain stimulation (aDBS) in patients previously stable on…Efficacy and Safety of IPX203 and Levodopa-Carbidopa Intestinal Gel (LCIG) Compared to Immediate-Release Carbidopa-Levodopa in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To conduct the efficacy and safety of IPX203, an extended-release carbidopa-levodopa formulation, and LCIG, a continuous levodopa infusion, compared to Immediate-Release Carbidopa-Levodopa (IR CD-LD)…Evaluation of Local Field Potential-guided DBS-programming in a Parkinson’s disease outpatient clinic
Objective: To evaluate potential use and applicability of local field potential-guided DBS-programming under real-life conditions in a Parkinson’s disease (PD) outpatient clinic. Background: Deep brain…Computer Vision Quantification of Repeated Finger Tapping Demonstrates Aberrant Plasticity in Parkinson’s Disease
Objective: Test if symptoms of Parkinson's disease (PD) develop through aberrant plasticity. Background: Recent results in 6-hydroxydopamine-lesioned mice show that repeated performance of simple motor…Correlations of catecholamine metabolites and alpha-synuclein by nigral stimulation in Parkinson’s disease model rat
Objective: We aimed to clarify the effects of substantia nigra (SN) stimulation on catecholamine levels and α-synuclein in PD model rats. Background: Catecholaminergic neurons are…Reduced Falls With ND0612: Supportive Analyses From the BouNDless Phase 3 Study
Objective: Explore potential reasons for the lower rates of falls with ND0612 vs immediate-release levodopa/carbidopa (IR-LD/CD) therapy reported in the BouNDless study. Background: Falls are…The Role of Research and Genetics Educational Events in Parkinson’s Research: Overcoming Barriers in the Hispanic Community
Objective: To assess the impact of educational events that emphasize research and genetics as well as culturally adapted recruitment strategies on increasing Hispanic participation in…Access to Allied Health Services by People Living with Parkinson’s Disease: A Qualitative Study
Objective: To determine the referral patterns of people with Parkinson’s disease (PwPD) to allied health from their perspective. Background: Allied health interventions can improve impairments…A Systematic Site Selection Approach to Ensure Efficient and Diverse Participant Recruitment to a Large-Scale Multi-Arm, Multi-Stage Platform Trial for Parkinson’s
Objective: To select up to 40 delivery sites to successfully recruit and retain a participant population representative of people with Parkinson’s disease (PwP) in the…The Feedback Loop: Illness Perceptions and Motor Complications in Parkinson’s
Objective: To explore the relationship between motor complications, illness perceptions and cognitive beliefs about symptoms in people with Parkinson's disease (PwP). Background: Around 50% PwP…
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