Targeting inflammation and autophagy: a dual-inhibition strategy to reduce α-synuclein pathology in GBA1-associated Parkinson’s disease
Objective: To assess the effects of combined inhibition of mTOR (autophagy regulator) and STING (inflammation regulator) on α-synuclein phosphorylation, tyrosine hydroxylase expression, and lysosphingolipid levels in…CSM-101 is a Small Molecule Agonist of TRPML1 for Parkinson’s-Related Disorders
Objective: (i) To develop a brain-penetrant small molecule agonist for the lysosomal TRPML1 channel and, (ii) Perform preclinical studies supporting development in Parkinson’s-related disorders. Background:…PHIT-Brain Study Protocol: Adaptation and Evaluation of a Multifaceted Brain Health Intervention for Patients with Parkinson’s Disease and Mild Cognitive Impairment (PD-MCI)
Objective: The aim is to adapt a brain health program for the PD population, the Parkinson’s Health Initiative for Thinking and the Brain (PHIT Brain),…Developing a Smartphone Application to Capture Objective Smartwatch Passive and Continuous Data to Individualize Parkinson’s Disease Patient Care
Objective: To describe a large health care organization’s process to develop a Parkinson’s Disease (PD) smartphone application (app) to provide individualized care to patients. Background:…Fecal Microbiota Transplantation for Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess Fecal Microbiota Transplantation (FMT) efficacy in improving Parkinson’s disease (PD) symptoms. Background: Dysregulation of the microbiome–gut–brain axis is a key pathophysiological mechanism…Organoid-Based AI Clinical Trial Platform for Phase 0 Studies in Parkinson’s Disease
Objective: we developed an organoid-based AI-driven platform to classify patient specific molecular subtypes and predict drug efficacy through an AI-powered validation pipeline. Patient-derived induced pluripotent…Inpatient Multimodal Care Improves Parkinsonian Symptoms Regardless Of Race Or Ethnicity
Objective: To verify demographic characteristics of patients with Parkinson’s disease (PD) completing a two-week inpatient multimodal intensive neurorehabilitation and care (iMINC) program and whether iMINC…Epigenome-wide and gene-targeted epigenetic profile of isolated REM Sleep Behaviour Disorder: a clinico-molecular study
Objective: Comprehensively characterize the epigenetic profile of isolated REM Sleep Behaviour Disorder (iRBD) using genome-wide and gene-targeted approaches, linking it to clinical measures and phenoconversion.…Mapping aggregate monopolar sensing data of beta power local field potentials onto a common subthalamic nucleus in Parkinson’s disease patients
Objective: Compare local field potential (LFP) magnitude and anatomical location measured from a chronically implanted deep brain stimulation (DBS) lead within the subthalamic nucleus (STN)…L1CAM and TMEM119 enriched Exosomal markers in Parkinson’s Disease and Progressive Supranuclear Palsy: A Prospective Study
Objective: This study explored longitudinal changes in cellular inflammatory, autophagic mediators in L1CAM and TMEM119-enriched exosomal samples of patients with Parkinson’s disease (PD) and Progressive…
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