MicroRNA Landscape of Multiple System Atrophy: Insights from Plasma and Patient-Derived Induced Pluripotent Stem Cell Models
Objective: To identify small non-coding RNAs (sncRNAs) signatures in multiple system atrophy (MSA) and elucidate their functional mechanisms within patient-derived induced pluripotent stem cell-differentiated oligodendrocytes…Traditional Deep Brain Stimulation Programming versus Automated Image-Guided Algorithm in Patients with Parkinson’s Disease
Objective: To compare traditional initial deep brain stimulation (DBS) programming with artificial intelligence (AI)-assisted automated image-guided DBS programming algorithm. Background: DBS programming is a complex,…Effect of Sensory Feedback Vibration Stimulation Using an In-Sole Foot Pressure Monitor on Gait
Objective: To investigate the effects of a sensory feedback vibration stimulation device that integrates an insole foot pressure sensor on gait. Background: Foot pressure during…Clustering and Identification of Parkinson’s Disease Severity Subtypes Using Multimodal Data and Machine Learning Approaches
Objective: This study aimed to classify Parkinson’s disease (PD) severity subtypes by integrating objective multimodal data with machine learning (ML) techniques. We applied unsupervised clustering…Temporal disease patterns prior to Progressive Supranuclear Palsy diagnosis
Objective: To identify Progressive Supranuclear Palsy (PSP) disease trajectories, defined as the pattern of diagnoses over time, prior to PSP diagnosis in electronic health records.…Longitudinal FDG-PET Study of Metabolic Trajectories and Connectivity Alterations in Multiple System Atrophy
Objective: 本研究使用 FDG-PET 探索 MSA 中葡萄糖代谢和网络连接的纵向变化，以辅助早期诊断和监测疾病进展。 Background: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease with distinct metabolic patterns in its parkinsonian (MSA-P)…An Interesting Case of Oculo-Palatal-Pharyngeal Tremor
Objective: We present a case report of a 59 year old with a diagnosis of clinically possible progressive supranuclear palsy (PSP) and clinical finding of…Natural history and epidemiological study of multiple system atrophy in Hokkaido: HoRC-MSA 2014-2025
Objective: To investigate epidemiological information of multiple system atrophy (MSA) patients in Hokkaido, Japan by using the registry data from the Hokkaido Rare-disease Consortium for…Parkinsonism Due to Delayed Neurotoxicity of CAR-T Therapy
Objective: We report a case of secondary parkinsonism due to delayed neurotoxicity induced by ciltacabtagene autoleucel (cilta-cel) chimeric antigen receptor T-cell therapy (CAR-T) as well…Gait Analysis and Outcome of CSF Drainage in Patients of Normal Pressure Hydrocephalus
Objective: NPH is a clinical entity causing impairment in gait, bladder and memory functions. Of these, gait dysfunction is the most prominent and disabling as…
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