Relationship between bradykinesia and cognitive functions in patients with essential tremor
Objective: To investigate the association between bradykinesia, i.e., movement slowness, as objectively assessed with kinematic analysis, and cognitive functions in ET. Background: Bradykinesia in essential…Cell-specific MAPT gene expression is preserved in tau cytopathologies in Progressive Supranuclear Palsy
Objective: To systematically map and quantify MAPT expression in neurons, astrocytes and oligodendroglia across different brain regions to determine whether cell type and/or regional differences…Timed-up-and-go tests under dual-task conditions: Influence of different tasks on gait parameters in Parkinsonian patients
Objective: To analyse the effect of dual tasking on the Parkinson gait. Background: Parkinson's disease has a strong impact on gait and posture, leading to…Bilateral staged MRI-guided focused ultrasound subthalamotomy for Parkinson’s disease
Objective: To assess the feasibility and safety of bilateral staged focused ultrasound subthalamotomy(FUS-STN) for Parkinson's disease(PD). Background: Unilateral FUS-STN for PD improves contralateral motor features…Design of a time-to-event study in GBA Parkinson’s Disease patients: Efficacy and safety of BIA 28-6156, an allosteric activator of beta-glucocerobridase (GCase)
Objective: To assess the efficacy of BIA 28-6156 in delaying clinically meaningful motor progression in PD patients who have a PD-risk associated variant in the…Dopamine depletion of striatal subregions and motor dysfunction in prodromal and clinical Parkinson’s disease
Objective: This aim of this study was to investigate how dopamine depletion of different striatal subregions contributes to motor symptoms in patients with prodromal and…local field potential differences in stn subregion during performance of a conflict task in humans with parkinson’s disease
Objective: Examine dorsal and ventral STN subregion's roles in motor conflict with intraoperative recordings during the implantation of a DBS device in Parkinson’s disease (PD)…Physical exercise as a promising option for treating fatigue in Parkinson’s disease? Results of a systematic review and meta-analysis of non-pharmacological interventions
Objective: To give an update on randomized controlled trials (RCT) including non-pharmacological intervention approaches that examine effects on fatigue in people with Parkinson’s disease (PD).…Real-life monitoring of Parkinson’s disease tremor: does the non-tremor subtype really exist?
Objective: To quantify daily-life tremor in Parkinson’s disease (PD) using a smartwatch containing a three-axis accelerometer and gyroscope. Background: Objective and continuous evaluation of PD…APOE-ɛ4 status and cognitive decline after subthalamic nucleus-deep brain stimulation in Parkinson’s disease: preliminary results of the GENEPARK-DBS study
Objective: The aim of this study was to evaluate wheter the presence of APOE-ε4 in a cohort of Parkinson’s disease (PD) patients treated with subthalamic…
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