Heterogeneity of multiple system atrophy with an analysis of the clinical case
Objective: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease clinically characterized by various combinations of Parkinsonism with resistance to levodopa, cerebellar, autonomic, and…Is cathepsin D a good target for therapy in Tau-related conditions?
Objective: To study the involvement of cathepsin D in the pathogenesis of Tau-related conditions. Background: The endo-lysosomal system (ELS) is central in processing of neurodegenerative…Brain De-Ironization with Nasal Spray of Iron Chelator in Treatment of Multiple System Atrophy, a Case Trial
Objective: Iron removal seems to be a treatment approach in Multiple system atrophy (MSA) because pathological findings shows the accumulation of iron and α-synuclein protein…Treatment Patterns and Comorbidities Associated with Multiple System Atrophy: A Comparative Study
Objective: To examine comorbidities and co-medications in patients with multiple system atrophy (MSA) compared to a matched-control in real-world setting Background: Currently MSA is managed…Clinical characteristics and Brain atrophy pattern in the prospective multicenter cohort of Progressive Supranuclear Palsy
Objective: This study aims to investigate volumetric brain MRI features, clinical parameters and their correlations in the Study of Comprehensive ANd multimodal marker-based Cohort of…Safety and Efficacy of the Anti-alpha Synuclein Monoclonal Antibody Lu AF82422 for the Treatment of Patients with MSA: Results from the Phase 2 AMULET Trial
Objective: Assess the efficacy and safety of monthly IV infusions with the anti-alpha synuclein [a-syn] monoclonal antibody Lu AF82422 for the treatment of patients with…Prevalence of autonomic symptoms in Multiple System Atrophy on the background of probable RBD
Objective: To discover whether having probable rapid eye movement sleep behavior disorder (RBD) affects prevalence of particular autonomic symptoms, namely falls, constipation and urinary incontinence…Unsupervised Learning Approach for Pathology-Based Subtyping and Staging Multiple System Atrophy
Objective: To develop a classification and staging system for multiple system atrophy (MSA) using data-driven disease progression modeling. Background: MSA exhibits varying degrees of degeneration…Lyme disease presenting as a rapidly progressive MSA-C look alike
Objective: We report two cases of encephalomyelitis due to Lyme disease with cerebellar ataxia and autonomic symptoms, which presented with a rapidly progressive MSA-like phenotype.…Inclusion of PSP-Parkinsonism (PSP-P) phenotype in clinical trials – power calculation
Objective: PSP-P is the second most common PSP phenotype. To facilitate its inclusion in future clinical trials, we used longitudinal data from the TAUROS study…
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