Legmain/Asparaginyl endopeptidase-resistant tau fibril fold produces corticobasal degeneration-specific C-terminal tau fragment
Objective: This study monitored the formation of CBD (corticobasal degeneration)-type fibrils that exhibit astrocytic plaques, a characteristic CBD pathology, using Legumain-cleavage site-specific antibodies and CBD-specific…Development and Validation of a Clinical Scale for Distinguishing Multiple System Atrophy from 4-Repeat Tauopathies
Objective: We aimed to develop a clinical scale that distinguishes between Multiple System Atrophy (MSA) and 4-repeat tauopathies (4RT: CBD, PSP) using a standardized neurological…Regional tau burden patterns and their associations with clinical severity in progressive supranuclear palsy (PSP)-Richardson’s syndrome and PSP- predominant parkinsonism: a prospective cohort study
Objective: To explore whether PSP-RS) and PSP-P have different regional tau burden distributions in the brain and whether these distributions are related to motor and…Is cathepsin D a good target for therapy in Tau-related conditions?
Objective: To study the involvement of cathepsin D in the pathogenesis of Tau-related conditions. Background: The endo-lysosomal system (ELS) is central in processing of neurodegenerative…Increasing diagnostic accuracy of Multiple System Atrophy – A Videolibrary on clinical and imaging features
Objective: To provide short, high-quality videos and MRI images presenting typical MSA features to supplement new MDS-MSA criteria1. Background: The MDS criteria for the diagnosis…Treatment Patterns and Comorbidities Associated with Multiple System Atrophy: A Comparative Study
Objective: To examine comorbidities and co-medications in patients with multiple system atrophy (MSA) compared to a matched-control in real-world setting Background: Currently MSA is managed…Paraneoplastic neurological syndrome mimicking a progressive supranuclear palsy: a case series
Objective: we describe 2 patients with paraneoplastic parkinsonism mimicking a PSP. Background: Paraneoplastic neurological syndromes (PNS) are broad-spectrum disorders that can affect any part of…Safety and Efficacy of the Anti-alpha Synuclein Monoclonal Antibody Lu AF82422 for the Treatment of Patients with MSA: Results from the Phase 2 AMULET Trial
Objective: Assess the efficacy and safety of monthly IV infusions with the anti-alpha synuclein [a-syn] monoclonal antibody Lu AF82422 for the treatment of patients with…Prevalence of autonomic symptoms in Multiple System Atrophy on the background of probable RBD
Objective: To discover whether having probable rapid eye movement sleep behavior disorder (RBD) affects prevalence of particular autonomic symptoms, namely falls, constipation and urinary incontinence…Unsupervised Learning Approach for Pathology-Based Subtyping and Staging Multiple System Atrophy
Objective: To develop a classification and staging system for multiple system atrophy (MSA) using data-driven disease progression modeling. Background: MSA exhibits varying degrees of degeneration…
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