Normal Pressure Hydrocephalus in Vestibular Schwannoma Patients
Objective: The first objective is to evaluate the potential pathophysiological link between vestibular schwannoma (VS) and normal pressure hydrocephalus (NPH) by analyzing clinical features, imaging…A rapidly progressive multiple system atrophy-cerebellar variant model presentingα-synuclein oligomer spreading and phosphorylated α-synuclein aggregate formation accompanied with glial inflammation
Objective: We aimed to develop a rapidly progressive mouse model that recapitulates MSA-C pathology. Background: Multiple system atrophy (MSA) is a severe α-synucleinopathy driven by…Case report and Literature Review on Atypical Parkinson’s Disease
Objective: Atypical parkinsonism is classified as a subgroup of Progressive neurodegenerative diseases, characterized by symptoms of Parkinson's disease. Background: Progressive supra nuclear palsy of the…Clinical subtypes and Radiological patterns in Progressive supranuclear palsy: A Prospective study
Objective: To subclassify Progressive supranuclear palsy (PSP) into cortical and subcortical typesTo identify the clinical and radiological correlation in PSP Background: The 2017 International Parkinson…Neuroinflammatory response is determined by HLA genotype in progressive supranuclear palsy
Objective: Our aim was to examine whether the HLA haplotypes influence the neuroinflammatory response in a cohort of neuropathologically diagnosed PSP cases. Background: Progressive supranuclear…Cutaneous Phosphorylated Alpha-Synuclein Deposition in Multiple System Atrophy
Objective: To report differences in the amount, localization and topographic distribution of cutaneous P-SYN deposition between cerebellar and parkinsonian variants of MSA. Background: MSA is…Connectome of Pathology Stages of Progressive Supranuclear Palsy
Objective: Find the relations between normative FC and seed-to-seed correlations in pathological tau load. Model the FC maps for twelve patients, using post-mortem tau pathology…PET and Clinical Evidence for Neuroprotective Effects of KM-819 on MSA
Objective: To assess the effect of KM-819 on the progression of multiple system atrophy (MSA). Background: Parkinson’s brain is associated with increased expression of the…Relationship Between Alpha-Synuclein Aggregation Profiles, Imaging Biomarkers, and Disease Severity in a Phase 2 Study of ATH434 in MSA
Objective: To investigate the relationships between α-synuclein aggregation profiles, imaging biomarkers, and UMSARS I scores in the ATH434-201 Phase 2 study. Background: Multiple system atrophy…Disease Characteristics of the First 100 Participants in the CurePSP Genetics Program Cohort
Objective: To increase our understanding of the pathogenesis of atypical parkinsonian disorders though genetics, and to build a cohort of individuals for future research. Background:…
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