IL-6 and motor symptoms in Parkinson’s disease
Objective: To assess the concentration of interleukin-6 (IL-6) in serum of patients with PD and its relation to motor symptoms. Background: Participation of inflammatory mechanisms…A whole brain anatomical network model and its application in PD research
Objective: To build a frame of whole brain anatomical network for incorporating different data from different studies with different brain parcellations and resolutions, to evaluate…LC3 deacetylation by SIRT1 is involved in neuroprotective effects of resveratrol in an MPTP mouse model of Parkinson’s disease
Objective: Our previous study has demonstrated that resveratrol (RV) enhanced clearance of misfolded α-synuclein proteins in cellular models of PD, with the activation of SIRT1…Neurodegeneration and microgliosis are independent of α-synuclein aggregation in a mouse model of "prion-like" α-synuclein speading
Objective: Our aim was to test if α-synclein aggregation drives neuronal demise and microglial activation in a murine model of induced-α-synucleinopathy. Background: Pathological α-synuclein aggregates…Involvement of peripheral immune system in the pathogenesis of Parkinson’s disease
Objective: To investigate the role of peripheral immune system in the pathogenesis of Parkinson's disease carrying LRRK2 risk variants. Background: Leucine-rich repeat kinase 2 (LRRK2)…Non-motor symptoms profiles in UK white Caucasian and Asian as well as overseas Thai and East Indian patients with Parkinson’s disease
Objective: To compare motor and non-motor symptoms (NMS) in white Caucasian (WC) and Asian patients with Parkinson's disease (PwP) living in the UK as well…Oral apomorphine film (APL-130277) produces no buccal mucosal irritation: Results of a toxicological study
Objective: Determine the tolerance of and potential for cheek pouch buccal mucosa irritation following the administration of apomorphine film (APL-130277). Background: APL-130277 is a sublingual…Differential vulnerability to α-synuclein pathology among neuronal subpopulations
Objective: To identify the cell death pathway(s) activated by α-synuclein (α-syn) pathology in an in vitro model of Lewy pathology and determine if neuronal subpopulations…Generation and characterization of midbrain organoids from iPSCs of familial Parkinson’s disease
Objective: To generate and characterize human pluripotent stem cell (iPSCs) - derived midbrain cerebral organoids of patients with Parkinson's disease. Background: Parkinson's disease is a…Phosphorylation by GSK-3β enhances binding of metal ion induced tau oligomers to neutral lipid surfaces
Objective: To dissect the complex interplay of tau hyperphosphorylation, metal ion induced oligomer formation and membrane interactions applying single particle fluorescence techniques. Background: Fibrillar deposits…
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