Utilizing latent class analysis to explore the sleep disturbance subtypes in Parkinson’s disease patients
Objective: The aim of this study was to analyze whether distinct sleep disturbance subtypes could be empirically identified in patients with Parkinson’s disease (PD) based…Quality of Life in Parkinson’s Disease: Impact of Depression and Apathy
Objective: The aim of this study is to investigate whether depression and apathy are independently related to QoL in patients with PD. Therefore, we performed…Serum Uric Acid Level and Its Relationship to Non-Motor Symptomatology in Parkinson’s disease
Objective: To determine the relationship between serum uric acid level and non-motor symptoms using the PD specific non-motor symptoms in Nigerian patients with Parkinson’s disease.…Long-term efficacy and safety of incobotulinumtoxinA treatment for sialorrhea in Parkinson’s disease and other neurologic conditions
Objective: SIAXI (NCT02091739), a pivotal double-blind, randomised, placebo-controlled study with a 48-week extension period (EP), assessed the efficacy and safety of incobotulinumtoxinA 75 U or…A Study of Pain in Parkinson’s Disease
Objective: To study the prevalence, type and severity of pain in patients with Parkinson’s disease. Background: Pain is one of the recognised non-motor symptoms in…New evidence for thalamic dysfunction in Parkinsonian rats
Objective: Abnormal oscillatory activity within the cortico-basal ganglia (BG)-thalamo-cortical circuit has been observed in Parkinsonian state, especially of β and γ bands (βB and γB).…The difference in posture reaction against backward perturbation between patients with Parkinson’s disease and healthy controls
Objective: To investigate the posture reaction in patients with Parkinson’s disease (PD) and healthy age-matched controls when they were given quantitative backward perturbation. Background: Although…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…Activation of chaperone-mediated autophagy reduces oligomeric alpha-synuclein accumulation in LRRK2(R1441G) knockin mouse model of Parkinson’s disease (PD)
Objective: To determine age-dependent accumulation of oligomeric alpha-synuclein in the brain of aged LRRK2(R1441G) knockin mice; and to explore whether activation of chaperone-mediated autophagy (CMA)…Prefrontal cortical stimulation to treat anxiety and depression in Parkinson’s disease
Objective: The aims of this study are 1) to study the neurophysiology underlying anxiety and depression in PD patients, and 2) to determine whether cortical…
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