Legmain/Asparaginyl endopeptidase-resistant tau fibril fold produces corticobasal degeneration-specific C-terminal tau fragment
Objective: This study monitored the formation of CBD (corticobasal degeneration)-type fibrils that exhibit astrocytic plaques, a characteristic CBD pathology, using Legumain-cleavage site-specific antibodies and CBD-specific…Combined application of alpha-synuclein and 4-repeat tau seed amplification assays for the differential diagnosis of parkinsonian disorders
Objective: To assess alpha-synuclein (a-syn) and 4-repeat tau (4RT) seed amplification assay (SAA) positivity rates in biosamples from people with Parkinson’s disease (PD) and Progressive…Hydrocephalic Progressive Supranuclear Palsy: An Underrecognized Entity
Objective: We describe a case of NPH-like presentation of PSP, review literature surrounding this entity, and discuss key diagnostic considerations and implications. Background: Despite advances…Path To Prevention (P2P) Therapeutics Platform Trial in Stage 2B Neuronal Alpha-Synuclein Disease: Study Update
Objective: To describe the study design and timeline of the first interventional study in Neuronal α-Synuclein Disease (NSD). Background: P2P is a platform, Phase 2…New α-Synuclein Strain Biomarker in Parkinson’s Disease and Related Dementia
Objective: Biomarker development for Parkinson’s disease and related dementia. Background: α-Synuclein (α-syn) strains can serve as discriminators of Parkinson's disease (PD) from other α-synucleinopathies. However,…Association of β-Amyloid Load on PET with Cognitive Profiles Across the Lewy Body Diseases Continuum
Objective: To investigate the association between Aβ accumulation and clinical characteristics across the Lewy body disease (LBD) spectrum, with a specific focus on global and…Trihexyphenidyl Use in a Parkinsonian Phenotype of Gerstman-Sträussler-Scheinker Syndrome
Objective: To highlight clinical improvement in a patient with a parkinsonian presentation of Gerstmann-Sträussler-Scheinker (GSS) syndrome who was treated with trihexyphenidyl. Background: GSS is a…Behind the wheel with Parkinson’s-Older patients’ review
Objective: To review characteristics of older Parkinson’s patients undergoing driving assessments presenting to Movements disorder’s clinic at Royal Berkshire Hospital, Reading,UK. Background: Parkinson’s leads to…Body Mass Index as a Possible Poor Prognostic Factor in Motor and Postural Condition Through the Evaluation of MDS-UPDRS 3.3 – 3.18 in Patients with Parkinson’s.
Objective: To determine the degree of motor and postural impairment of patients with Parkinson's Disease at the time of their first consultation according to the…Disease-related comprehensive motor pattern derived from 2D single RGB video as a biomarker for early and prodromal Parkinson disease
Objective: This study aims to develop a disease-related motor pattern from a single 2D RGB video as a biomarker for early diagnosis and monitoring of…
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