Relationship between automatic analysis of gait disorder and eye movement capture by AI and cognitive function in Parkinson’s disease
Objective: Gait disorder is a hallmark of Parkinson’s disease (PD), with mounting evidence linking gait to cognitive function in PD patients and eye movements serving…Peripheral Inflammatory Markers and Clinical Correlations in Parkinson’s Disease Patients Carrying LRRK2 G2385R and R1628P Variants
Objective: To investigate plasma cytokines and chemokines with clinical correlations between Parkinson’s disease (PD) patients carrying LRRK2 p.G2385R and/or p.R1628P variants, idiopathic PD (iPD), and healthy controls.…MDSGene literature update on autosomal recessive Parkinson’s Disease
Objective: To comprehensively characterize demographic, genetic, and phenotypic features in individuals with autosomal recessive Parkinson’s disease (PD), leveraging individual-level data from published literature. Background: In…Safety and Effectiveness of DaxibotulinumtoxinA in Cervical Dystonia: A Systematic Review and Meta-Analysis of Different Doses
Objective: To evaluate the effectiveness and safety of DaxibotulinumtoxinA (DAXI) in patients diagnosed with cervical dystonia (CD). Background: Botulinum toxins (BoNTs) are the first-line therapy…Comparison of Regional Perfusion Patterns in Clinical Subtypes of PSP and CBD: Dual Phase [¹⁸F]FP CIT PET Study
Objective: To investigate the regional perfusion patterns using PET imaging across various clinical subtypes of PSP and CBD. Background: On MRI, PSP typically shows midbrain…Restoring the Axis: Efficacy of Fecal Microbiota Transplantation (FMT) on Motor and Non-Motor Symptoms in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2023–2025)
Objective: To methodically assess the safety and effectiveness of fecal microbiota transplantation (FMT) in comparison to a placebo for Parkinson's disease (PD) patients' motor and…A case series of Spinocerebellar ataxia subtype 15 from Chile
Objective: To describe a series of patients in Santiago Chile with genetically confirmed SCA15. Background: Spinocerebellar ataxia (SCA) are genetic neurodegenerative diseases for which SCA…Non-Motor Symptom Burden as a Key Determinant of Disease Clustering in Parkinson’s Disease
Objective: To evaluate how non-motor symptoms drive the classification of Parkinson’s disease (PD) patients beyond standard motor subtyping. Background: While motor symptoms are the hallmark…Role and significance of C-reactive protein in stages of Parkinson’s disease
Objective: To сomparative analysis of the amount of CRP in the blood serum of patients according to the stages of PD. Background: C-reactive protein (CRP)…The Transcriptomic, Neurotransmitter, and Cell Type Signatures Underlying Pure Fatigue in Early-stage Parkinson’s Disease
Objective: This study elucidates spatiotemporal functional connectivity of pure fatigue in early Parkinson’s disease (PD) and uncovering underlying gene expression profiles. Background: Fatigue is a…
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