Fractionating apathy – Effort, reward and impulsivity mechanisms in Parkinson’s and Huntington’s disease
Objective: Refine understanding of the processes underpinning apathy in neurodegenerative disease, by identifying 1) objective measures to assess apathy; 2) parcellating the broad construct of…Reward insensitivity differentiates apathy from depression in Parkinson’s disease
Objective: To determine if a potential cause of apathy in Parkinson's disease (PD) might be insensitivity to rewards, establish if this differentiates apathy from depression…Screening for neuropsychiatric symptoms in Parkinson’s disease
Objective: To determine the convergent validity of the screening questions included in instructions to patients for Part 1A of the International Parkinson and Movement Disorder…Effect of STN-DBS on impulse control disorder and affective behavioral complications of Parkinson’s disease: A 1-year longitudinal study
Objective: In this 1-year prospective study, we evaluated the effect of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on neuropsychiatric complications of…A new tool to measure the impact of deep brain stimulation on Parkinson’s disease patients: Development and validation of the deep brain stimulation impairment scale (DBS-IS)
Objective: To develop a questionnaire that measures impairments related to deep brain stimulation (DBS). Background: DBS has considerable influence on motor and non-motor symptoms in…Motor and non-motor symptoms in Parkinson’s disease: Correlation and impact on quality of life and activities of daily living
Objective: To evaluate the prevalence, interrelation and impact on health related quality of life (HRQL) and Activities of daily Living (ADL) of motor (MS) and…Apathy and striatal dopamine defects in non-demented patients with Parkinson’s disease
Objective: We performed this study to investigate whether dopamine depletion in the ventral striatum contributes to apathy in PD. Background: Apathy is a common, disabling…Impact of subclinical apathy prior to deep brain stimulation on the quality of life of patients with Parkinson’s disease
Objective: To evaluate the influence of pretreatment subclinical apathy on patient QOL following subthalamic nucleus DBS (STN-DBS) in PD patients 12 months after surgery. Background:…Relationship between the MDS-UPDRS and quality of life in Parkinson’s disease: A large international multicenter study of 3206 patients (the QUALPD study)
Objective: To evaluate the relationship between the International Parkinson and Movement Disorder Society – Unified Parkinson's disease Rating Scale (MDS-UPDRS) and Quality of Life (QoL)…Relationships of cognitive functions and psychiatric symptoms with motor phenotypes in patients with untreated early-stage Parkinson’s disease
Objective: It has been shown that the clinical types of Parkinson's disease (PD) based on motor symptoms include motor phenotypes of postural instability and gait…
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