Off-painfull state in Parkinson’s disease patients: A redflag of complulsive behavior. Data from a PET-FDG study
Objective: The aim of this study was to investigate the neural underpinnings of the dopaminergic dysregulation syndrome( DDS ) during the “off-phase”. Background: The DDS…Striatum of the ouabain-induced pharmacological DYT12 mouse model is affected by structural and metabolic abnormalities
Objective: To study changes in neuronal morphology and neurotransmitter metabolism in the striatum of a pharmacological DYT12 mouse model after induction of a dystonic phenotype…No differences in the total burden of non-motor symptoms between Parkinson’s disease and non-degenerative parkinsonism
Objective: To compare the total burden of non-motor symptoms between Parkinson's disease and non-degenerative parkinsonism and to study the possible dopaminergic background of these symptoms.…Dopaminergic neurons in Substantia Nigra pars compacta code the vigor of movement sequences
Objective: Assess the correlates of movement vigor in Substantia Nigra dopaminergic neurons Background: Current basal ganglia models have focused on the role of dopamine in…Levodopa and subthalamic stimulation do not have the same effect on subjective cost for distal and axial efforts in Parkinson’s disease
Objective: To compare the effects of levodopa and subthalamic nucleus stimulation (STN-DBS) on decision-making tasks for distal (hand) and axial (speech) efforts in Parkinson’s disease…Neurohormetic properties of mild physical stress against Parkinson’s disease phenotype
Objective: To test whether routine mild physical stress acts as a hormetic strategy against Parkinsonian symptoms among mice. Background: Regular physical exercise is suggested to…New evidence for thalamic dysfunction in Parkinsonian rats
Objective: Abnormal oscillatory activity within the cortico-basal ganglia (BG)-thalamo-cortical circuit has been observed in Parkinsonian state, especially of β and γ bands (βB and γB).…The effects of sensory reward cues on risky decision making in Parkinson’s disease
Objective: To evaluate the effects of sensory reward cues on risky decision making in unmedicated and medicated Parkinson’s disease (PD). Background: Cue reactivity may play…Motivational effects on action selection and memory
Objective: Eye movements provide important insights into the pathophysiology of neurological disorders. Here two paradigms were devised to quantify effects of motivation on motor control…Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats
Objective: (1) Curcumin is well tolerated curcuminoid used as supplement for various disorders but problem is its low oral bioavailability. (2) Piperine is combined to…
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