Brain neurotransmitters and neuropeptides alternations in Parkinson’s induced mouse models
Objective: Present study aimed to investigate the changes in brain neurotransmitters and neuropetides in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models of PD. Background: Parkinson’s disease (PD), a…Decreased serum alpha-synuclein in patients with Restless Legs Syndrome and association with SNCA-Rep1 polymorphism
Objective: To investigate whether α -synuclein levels are altered in serum and saliva in patients with RLS and explore influence of the SNCA-Rep1 microsatellite repeat…Quercetin administration abrogates the Parkinson’s disease (PD)-like motor and non-motor symptoms and attenuates the behavioral, neurochemical and biochemical deficits induced by rotenone toxicity in rats
Objective: The present study was carried out to investigate the preventive and therapeutic effects of quercetin (a flavonol) against rotenone-induced neurotoxicity. Background: Rotenone (pesticide) induced…Movement Disorders in Post Stroke Patients: A Retrospective Analysis
Objective: To review the prevalence of various movement disorders in post stroke patients at a tertiary, academic center and to characterize the therapeutic response to…How Parkinson’s Disease Affects Value-Based Decisions
Objective: Parkinson’s Disease (PD) is a degenerative motor disease that causes subtle deficits in decision-making as a result of striatal dysfunction due to dopamine depletion.…Neurohormetic properties of mild physical stress against Parkinson’s disease phenotype
Objective: To test whether routine mild physical stress acts as a hormetic strategy against Parkinsonian symptoms among mice. Background: Regular physical exercise is suggested to…New evidence for thalamic dysfunction in Parkinsonian rats
Objective: Abnormal oscillatory activity within the cortico-basal ganglia (BG)-thalamo-cortical circuit has been observed in Parkinsonian state, especially of β and γ bands (βB and γB).…The effects of sensory reward cues on risky decision making in Parkinson’s disease
Objective: To evaluate the effects of sensory reward cues on risky decision making in unmedicated and medicated Parkinson’s disease (PD). Background: Cue reactivity may play…Motivational effects on action selection and memory
Objective: Eye movements provide important insights into the pathophysiology of neurological disorders. Here two paradigms were devised to quantify effects of motivation on motor control…Neuroprotective potential of curcumin in combination with piperine against 6-hydroxy dopamine induced motor deficit and neurochemical alterations in rats
Objective: (1) Curcumin is well tolerated curcuminoid used as supplement for various disorders but problem is its low oral bioavailability. (2) Piperine is combined to…
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