Evaluation of neuroprotection by human ENGRAILED-1 in a chronic AAV-hα-synuclein-A53T (AAV-A53T) rat model of Parkinson Disease
Objective: Investigate the long-term neuroprotective effect of a single bilateral injection of human ENGRAILED1 (hEN1) in a rat α-synuclein model of Parkinson Disease (PD). Background:…Molecular Integration in Neurological Diagnosis (MIND): A Center-Wide Approach to Improve Molecular and Genetic Characterization of Parkinson’s Disease
Objective: To develop a clinical and genetic repository of all patients with Parkinson’s disease at The University of Pennsylvania Parkinson’s Disease and Movement Disorders Center…An investigation of the potential neuroprotective role of curcumin in Parkinson’s disease patient-derived fibroblasts
Objective: To investigate if the protective effects of curcumin previously observed in SH-SY5Y cells are also found in patient-derived fibroblasts from Parkinson’s disease patients. Background:…Prevalence of Single Nucleotide Polymorphisms (SNPs) rs362307 or rs362331 in Patients with Huntington’s Disease
Objective: An observational research study is being conducted in patients with Huntington’s disease (HD) to determine the frequency with which the thymine (T) variant of…Therapeutic exposures of CX-8998, a potent, selective and state dependent Cav3 channel antagonist in development for Essential Tremor and Parkinson’s disease Tremor in Cav3 driven neurological models
Objective: In this study, we utilized preclinical data to establish predicted human therapeutic exposures of the potent, selective and state-dependent Cav3 channel antagonist, CX-8998, currently…Motor and cognitive deficits in a mouse model of tauopathy with tau isoforms imbalance: Potential therapeutic strategies
Objective: This work investigates motor phenotypes and neurochemical changes in a mouse model of tauopathy linked to tau mis-splicing. We sought to validate a potential…A Phase 2 Efficacy Study of CX-8998, a Potent and Selective T-Type Calcium (Cav3) Modulator in Parkinson’s disease Tremor (PDT) Patients: Design and Dose-Selection Rationale
Objective: The objective of this study is to access the efficacy of CX-8998 using the MDS-UPDRS Tremor Score (MDS-UPDRS-TS) and a digital biomarker platform, while…Trans-spinal direct current stimulation for managing primary orthostatic tremor
Objective: To evaluate in a randomized, double-blind, sham-controlled, crossover trial the efficacy of non-invasive trans-spinal direct current stimulation (tsDCS) for managing primary orthostatic tremor (POT).…Design and Status of the BIIB054 SPARK Trial
Objective: To describe the design and status of the BIIB054 SPARK trial of the safety and potential efficacy of a monoclonal antibody (mAb) targeting alpha-synuclein…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…
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