B lymphocytes may be protective in early Parkinson’s disease and in an animal model of dopaminergic cell death
Objective: To investigate B lymphocyte phenotype and function in human PD and in an animal model of disease. Background: The clinical course in Parkinson’s disease…Pharmacological modulation of lysosomal glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson’s disease
Objective: To study the pharmacological modulation of glucocerebrosidase activity in the Thy1-aSYN mouse model of Parkinson's disease (PD). Background: PD is a complex neurodegenerative disorder…Nanoscale imaging reveals disorganization of the brain extracellular space in Lewy body-injected mice
Objective: To explore the brain extracellular space and its matrix at a nanometric scale in a context of α-synuclein-induced neurodegeneration. Background: The extracellular space (ECS)…Tetrahydroisoquinoline Molecule Identified in Traditional Ayurveda Medicine Modulates Inflammation in MPTP Mice
Objective: Potential ‘Anti-parkinsonian’ activity of a tetrahydroisoquinoline (TIQ) molecule of traditional ‘Ayurveda’ medicine was tested in a preclinical MPTP mice model for Parkinson’s disease (PD).…Molecular immunological action and epigenetic modification of the human papillomavirus vaccination and associated neuropsychiatric side effects
Objective: To investigate the clinical manifestations of neuropsychiatric side effects after the Human papillomavirus (HPV) vaccine, and to investigate the immunological actions and epigenetic modification.…T lymphocytes in Parkinson’s disease pathogenesis and therapy: A systematic review
Objective: A systematic literature review was conducted to synthesize the current state of knowledge on the role of T lymphocytes in Parkinson’s disease (PD) pathology…Dopaminergic impairments following repeated exposure to stress on the neurotoxicity of lambda-cyhalothrin through inflammatory cytokines in rats
Objective: Impact of psychological stressors in modulating the toxicity of environmental chemicals has been suggested, however the mechanism this is not clear. Background: Repeated stress…Soluble TREM2 and Central and Peripheral Inflammatory Biomarkers in Parkinson’s Disease
Objective: Given that Parkinson's disease (PD) may be associated with TREM2 and given that a soluble TREM2 (sTREM2) isoform has been described as elevated in…Effects of PGE inhibition on Striatal Neuroinflammation in 6-OHDA lesion
Objective: In this study, we investigated the role of prostaglandin E2 inhibition, pro-inflammatory cytokine concentration and microglial activation in a Parkinsonian rat Background: Neuro-inflammation plays…Microbiota DNA in the blood of patients with Parkinson’s disease
Objective: The aim of this study was to explore the blood microbiota compositions in Chinese patients with Parkinson’s disease (PD). Background: Emerging evidences suggest that…
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