Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson’s disease patients with type 2 diabetes mellitus
Objective: Identifying the risk factors of dementia in patients with both Parkinson’s disease (PD) and type 2 diabetes mellitus (DM) (PD-DM) is clinically relevant and…Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
Objective: Given the presence and function of SRY in male DA (dopamine) neurons, we hypothesised that dysregulation of SRY may contribute to male susceptibility to…Association of Interleukin (IL)-2 and IL2RA gene polymorphisms with Parkinson’s disease in Taiwan
Objective: The purpose of this study is to investigate if interleukin 2 (IL-2) and interleukin 2 receptor alpha (IL2RA) genes are associated with Parkinson’s disease…Multiplex biomarker discovery for diagnostic and progression markers for Parkinson’s disease with the proximity extension assay technology on inflammation-related analytes
Objective: To identify diagnostic and progression biomarkers in the longitudinal DeNoPa cohort of (at enrolment) de novo Parkinson’s disease (PD) and healthy controls (HC) using…Salivary proteome in Parkinson’s disease
Objective: The purpose of this paper is to characterize salivary proteome in PD comparing to healthy subjects using proteomic approach. Background: Parkinson’s disease (PD) is…Feasibility of Studying the PD Microbiome in Frozen Saliva and Formalin-Fixed Colon From the Systemic Synuclein Sampling Study (S4)
Objective: To examine feasibility of obtaining microbiome data from frozen saliva and formalin-fixed, paraffin-embedded (FFPE) colon specimens. Background: The gastrointestinal tract microbiome is of great…Microglial activation associated with a faster progression of nigrostriatal dysfunction in patients with isolated REM sleep behavior disorder
Objective: To assess the role of early microglial activation on the progression of nigrostriatal dysfunction, measured with 18F-DOPA PET, in isolated REM sleep behavior disorder…Regional free-water differentially associated with glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease
Objective: Assess to what extent free-water(FW) as measured by diffusion-weighted MRI(dMRI) is a neuroimaging marker of glial activation, neuroinflammation, and neurodegeneration in de novo Parkinson’s disease(PD) patients from…CSF inflammatory cytokines and correlation with clinical features in early, untreated PD patients
Objective: The aims of the present study were to investigate the levels of inflammatory cytokines in the cerebrospinal fluid (CSF) of drug-naïve Parkinson's Disease (PD)…Disease progression characterized by motor performance, dopaminergic neurodegeneration and T cell infiltration in the transgenic hm2-α-SYN-39 mouse model of Parkinson´s disease
Objective: To study disease progression in the transgenic (tg) hm2-α-SYN-39 mouse model of Parkinson´s disease (PD) by assessment of motor performance, dopaminergic neurodegeneration and T…
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