Combining Machine Learning and Linear Mixed Models to Estimate Medication Effect in People with Parkinson’s Disease
Objective: To estimate medication effect, as the score difference between MDS-UPDRS III in OFF and ON-state, using a minimal set of clinical features. Background: The…A Study Of Axial Postural Abnormality In Parkinson`s
Objective: APA involves distinct modes plus sequence patterns and proven predictors for every APA remains mystery. The goal is to probe the progress of APA…A Phase II Randomized, Parallel, Double-blind, Placebo-controlled Study of the Efficacy and Safety of WD-1603 in Subjects with Parkinson’s Disease
Objective: To investigate the effectiveness, safety and pharmacokinetics of WD-1603 carbidopa-levodopa controlled-release tablets in subjects with Parkinson's disease. Background: The development of drug products that…Influence of age at onset on medication profile in patients with Parkinson’s disease: A prospective study from a tertiary care center in India
Objective: To study the effect of age at onset on the medication profile of various Parkinson's disease (PD) related medications. Background: Multiple factors determine the…The effect of vortioxetine and mirtazapine on levodopa-induced dyskinesia in a rat model of Parkinson’s disease
Objective: To investigate the effect of vortioxetine and mirtazapine on levodopa-induced dyskinesia (LID) in a rat model of Parkinson’s disease (PD), we analyzed abnormal involuntary movements (AIMs)…Long-Term Effect of Opicapone in Parkinson’s Patients Without Motor Complications: 1.5-year EPSILON Study Findings
Objective: We report motor function, motor complication and tolerability findings of the EPSILON study up to 1.5 years. Background: The 24-week, double-blind, placebo-controlled Phase III…The Impact of Levodopa on Gait in Parkinson’s Disease: A Quantitative Analysis of Striatal Dopamine Transporter Availability and Lateralization
Objective: This study aimed to analyze gait changes in Parkinson’s disease (PD) patients before and after levodopa administration, examining correlations between gait parameters and striatal…Assessing the potential association of rs2298383 in ADORA2A as a predictor of Levodopa-Induced Dyskinesia in Latin American Parkinson’s Disease patients
Objective: To analyze the association between ADORA2A-rs2298383 and levodopa induced dyskinesias (LID) in a cohort of Latin American Parkinson’s disease patients. Background: Previous evidence has…Computer Vision Quantification of Repeated Finger Tapping Demonstrates Aberrant Plasticity in Parkinson’s Disease
Objective: Test if symptoms of Parkinson's disease (PD) develop through aberrant plasticity. Background: Recent results in 6-hydroxydopamine-lesioned mice show that repeated performance of simple motor…Mucuna pruriens for FOG in Parkinson’s disease, Do we have a solution for this trivial problem?
Objective: To study the effects of Mucuna Pruriens when administered via inhalation route, to alleviated symptoms of Parkinson's disease most importantly freezing of gait. Background: Mucuna…
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