Pallidal surgery and physiological mechanism in choreic movements
Objective: To investigate the effect of deep brain stimulation (DBS) or coagulation of the internal globus pallidus (GPi) for choreic movements of various disorders and…Neuromuscular electrical stimulation for the treatment of jaw-closing dystonia
Objective: To measure whether neuromuscular electrical stimulation (NMES) increases jaw-opening distance and improves quality-of-life in jaw-closing dystonia patients. Background: An index case with progressive supranuclear…Correlations between genetics and cortical dysfunction of paroxysmal kinesgenic dyskinesia
Objective: To delineate the cortical function of paroxysmal kinesigenic dyskinesia (PKD) and correlate with the genotypes of patients. Background: PKD is characterized by episodic involuntary movements…Characterization of the motor phenotype and striatal muscle analysis in a mouse model of hereditary spasticity
Objective: Characterize the motor phenotype and contractile force characteristics of skeletal plantar flexor muscles in a mutant mouse model for spasticity. This model displays a…Impact of cathine and carthinone use among Parkinson’s disease Patients
Objective: Evaluate cathine and cathinone’s effect on alertness, energy, sleep pattern, and tremor among Parkinson’s disease patient. Background: Khat, a plant that contains amphetamine like…Asymmetrical striatal dopamine transporter binding correlates with excess contralateral rest tremor
Objective: To investigate the relationship between striatal dopamine transporter binding and rest tremor. Background: In vivo dopamine transporter imaging is a useful tool for distinguishing…The utility of electrophysiological tests in the differentiation of upper limb tremor in young-onset patients
Objective: To explore the diagnostic utility of neurophysiologic tests in young-onset patients who present primarily with upper limb action tremor. Background: In young-onset patients, isolated…Closed loop spinal cord stimulation restores locomotion and desynchronizes corticostriatal beta oscillations
Objective: To test if closed loop Spinal Cord Stimulation (SCS) could be used to restore locomotion in a 6-hydroxydopamine (6-OHDA ) rodent model of Parkinson's…Long-term and dopamine dependent dynamics of subthalamic nucleus local field potentials in Parkinson’s disease
Objective: Using a new deep brain stimulation (DBS) pulse generator device that can record local field potentials (Activa PC+S, Medtronic Inc.), the current experiment investigated…Remote patient monitoring with a digital biomarker approach generates clinically distinctive and meaningful sensor feature data in Parkinson’s disease: Differential relationships with MDS-UPDRS-III, PDQ-39 and DaT-SPECT
Objective: To determine whether sensor features derived from remote smartphone testing in Parkinson’s disease (PD) predicted clinical, quality of life and biomarker measures collected in…
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