Assembling a Cohort of Hyposmic Participants for Therapeutic Studies Aimed at Parkinson’s Disease (PD) Prevention
Objective: The goal of this project was to amass a cohort of individuals with hyposmia to later invite them to participate in clinical trials for…Identifying Subjects with Dopamine Transporter Deficit in a Population-based Recruitment Strategy: Kassel Data of Healthy Brain Ageing
Objective: To identify subjects with dopamine transporter (DaT) deficit being at high risk for prodromal PD. Background: Neurodegeneration and dopaminergic deficit in PD occur before the development…Loganic Acid Alleviates the Bidirectional Olfactory-Brain NLRP3 Inflammasome Activation and Rescues Dopaminergic Neurons in Experimental Models of Parkinson’s Disease
Objective: The study aimed to delineate the molecular mechanism involved in bidirectional olfactory-brain dysfunction through the NLRP3 inflammasome signaling activation in in-vitro and in-vivo model…First in vivo evidence of the role of the noradrenergic system in olfactory dysfunction in Parkinson’s disease
Objective: To investigate the relationship between in vivo noradrenergic markers and olfactory impairment in patients with Parkinson’s disease (PD). Background: Degeneration of the noradrenergic (NA)…Understanding the earliest phases of Parkinson’s disease (PD) – an expanding opportunity to study ‘at-risk’/early/prodromal PD in the Global Parkinson’s Genetics Program (GP2)
Objective: To identify and recruit at-risk/early/prodromal Parkinson’s disease (PD) cohorts around the world to the Global Parkinson’s Genetics Program (GP2, http://gp2.org/) and build a global…Bidirectional Relationship Between Olfaction and Parkinson’s Disease
Objective: To establish a causal direction and genetic relationship between olfactory function and Parkinson’s disease (PD). Background: Degradation in olfactory function or hyposmia is a…Olfactory and taste function in early Parkinson’s disease with mild cognitive impairment
Objective: The purpose of this study was to compare olfactory and taste function between early drug-naive Idiopathic Parkinson's disease (IPD) patients with or without mild…Clinical correlates of olfactory dysfunction in Huntington’s disease
Objective: To assess olfactory dysfunction in patients with HD and correlate the degree of olfactory dysfunction with symptomatic domains of HD. Background: Olfactory dysfunction is…Alterations of the Right Olfactory Orbitofrontal Cortex and olfactory impairment in Parkinson’s Disease
Objective: To explore the potential role of the right olfactory orbitofrontal cortex in olfactory dysfunction (OD) in Parkinson’s Disease (PD). Background: The orbitofrontal cortex (OFC)…Polyaromatic hydrocarbons in Ambient Particulate Matter (PM 2.5) mediate neurodegeneration through the olfactory-brain axis in C57BL/6 mice
Objective: To delineate the molecular mechanisms involved in bidirectional olfactory-brain-induced neurodegeneration caused by exposure to ambient particulate matter (PM2.5). Background: Air pollution has been linked…
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