Design and discovery of 1,2,4 triazole derivatives as adenosine A2A receptor antagonist against parkinson’s disease
Objective: In the present study, we intended to develop novel 1,2,4 triazole as potent A(2A)AR antagonists against parkinson’s disease. Background: Parkinson’s disease (PD) is a…Treatment of secondary movement disorders related to midbrain cavernomas
Objective: To evaluate possible efficacy and safety of standard antiparkinsonian drugs (levodopa formulations, amantadine) in patients with symptomatic midbrain cavernomas (haemorhage and/or surgery) and secondary…Piperine potentiate the neuroprotective effect of quercetin against MPTP induced neurotoxicity in rats
Objective: (1) Quercetin is well tolerated bioflavonoid used as supplement for various disorders but problem is its low oral bioavailability and (2) Piperine is combined…The clinical profile associated to Amyloid-beta 42 and Tau cerebrospinal fluid levels in non-demented PD patients
Objective: To define cerebrospinal fluid (CSF) levels of Amyloid-beta 1-42 (Aß1-42-), total (h-) and phosphorylated (p-)Tau in a large cohort of non-demented Parkinson’s disease (PD)…Interval from onset of Parkinson disease to onset of motor and non-motor complications in Leucine-rich repeat kinase 2 (LRRK2) G2019S positive versus matched PD controls
Objective: To compare the latency between onset of Parkinson disease (PD) symptoms and onset of motor and non-motor complications of PD, between G2019S LRRK2 mutation…Genetic, epigenetic and expression profiles in alpha-synucleinopathies
Objective: To determine whether each of the alpha-synucleinopathies has distinct methylation and/or expression profiles that distinguishes them from other disorders in this class. Background: The…Baseline Clinical Predictors of Future Psychotic Symptoms in de novo Parkinson Disease
Objective: To determine which baseline clinical symptoms are associated with future psychotic symptoms in de novo Parkinson disease (PD). Background: Because psychosis in PD is…How do Parkinson’s Disease patients manage Ramadan Fasting?
Objective: To describe how Parkinson's disease(PD) patients manage Ramadan fasting and the impact of the fasting period on symptoms Background: Although Ramadan fasting is not…Rehabilitation program with or without a whey protein-based nutritional support enriched with essential aminoacids and vitamin D in patients with Parkinson’s disease or parkinsonism: study design of a randomized, controlled trial.
Objective: Objective. To evaluate whether the use of a whey protein-based nutritional formula enriched with essential aminoacids – particularly leucine - and vitamin D have…Self Perception of Dysphagia in Parkinson Disease
Objective: To determine when individuals with Parkinson disease (PD) perceive impairment of swallowing as it relates to time since diagnosis. Background: Dysphagia, and particularly silent…
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