Mitochondrial dysfunction in skin fibroblasts from single heterozygous ATP13A2 (PARK9) mutation carriers
Objective: To investigate the pathogenic effect of single heterozygous mutations in ATP13A2, we determined the function and morphological changes of mitochondria in skin fibroblasts derived…Gait impairment is more than a motor symptom in Parkinson’s disease
Objective: To examine the relationship of gait impairment of Parkinson's disease (PD) patients with different clinical factors including motor function, non-motor function and cognitive function.…Mitochondrial response precedes intracellular accumulation of α-synuclein in Parkinson’s disease
Objective: To investigate the expression of mitochondrial COX-IV during the progression of Parkinson's disease. Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the…Gender-age features of autonomic heart rhythm disturbances in Parkinson’s disease patients
Objective: To determine the gender differences and age-dependent features of autonomic heart rhythm disturbances in patients with Parkinson's disease (PD). Background: Autonomic heart rate failures…Minimum MDS-UPDRS part III change needed to convert a Parkinson’s disease patient from the OFF to full ON state with apomorphine sublingual film (APL-130277)
Objective: Determine the minimum MDS-UPDRS Part III improvement needed to convert a patient from the morning OFF state to a full ON with APL-130277. Background:…Apocyanin ameliorates post-stroke movement disorder in rats: Possible role of neurochemical and inflammatory alterations
Objective: To study the neuroprotective efficacy of apocynin, a NADPH oxidase inhibitor in 1) alterations of post- stroke motor behaviour, 2) alterations of various neurotransmitter…Evaluation of parkinsonism and striatal dopamine transporter loss in patients with spinocerebellar ataxia type 6
Objective: To study whether spinocerebellar ataxia type 6 (SCA6) patients have parkinsonism and striatal dopamine transporter (DAT) loss compared to gender- and age-matched healthy controls.…Resting state functional connectivity in olfactory network in de novo Parkinson’s disease
Objective: To assess the pattern of RS functional connectivity in PD patients, related to olfactory psychometric test, to elucidate olfactory-dependent cortical-subcortical functional networks. Background: Olfactory…Parkinson’s disease (PD) quality improvement measures (QIM) and outcomes study
Objective: To investigate whether adherence to PD QIMs affect patient outcomes. Background: The development of QIMs is linked to the belief that physician reimbursement should…Research of vestibular evoked myogenic potentials (VEMP) in the diagnosis of postural instability in Parkinson’s disease
Objective: To investigate the sacculocervical reflex of patients with PD with the assessment of changes of the parameters of VEMP depending on the severity of…
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