Alpha synuclein BAC transgenic mice as a preclinical model for disease-modifying therapies in Parkinson’s disease
Objective: The aim of this study is to make preclinical mice models for disease-modifying therapies in Parkinson's disease. Background: The prodromal stage of Parkinson's disease…Severity of Motor Symptoms in Parkinson’s Disease in Kazakhstan (on the example of the city of Almaty)
Objective: Determine the severity of motor symptoms with Parkinson's disease using the MDS-UPDRS scale. Background: Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by…The Association of Taichi to Delayed Progression of Parkinson’s Disease
Objective: To discover the effect of physical exercise on motor and non-motor symptoms in Parkinson’s disease (PD), and to explore whether physical exercise could delay…A Long-Term Safety, Tolerability, and Efficacy Study of Apomorphine Sublingual Film for On-Demand Treatment of “OFF” Episodes in De Novo vs Rollover Patients With Parkinson’s Disease: Interim Results
Objective: Evaluate long-term safety (LTS), tolerability, and efficacy of apomorphine sublingual film (APL-130277; APL) for on-demand treatment of “OFF” episodes in de novo (DN) vs…Remote video-based research visits in a phase 3 clinical trial in Parkinson’s disease
Objective: To assess the feasibility, reliability, and value of remote visits in a phase 3 trial of individuals with Parkinson's disease (PD). Background: Remote video-based…Positive Correlations Between Quality of Life and Sleep Dysfunction in Advanced Parkinson’s Disease Patients Prior to and After 12 Months of Levodopa-Carbidopa Intestinal Gel Treatment: An Analysis From the DUOGLOBE Study
Objective: To evaluate the relationship between sleep disturbances and quality of life (QoL) in advanced Parkinson’s disease (PD) patients both prior to and at month…Quantitative study of T-type Ca2+ channels in the subthalamic nucleus neurons towards Parkinson’s disease
Objective: From the pathophysiological perspectives, Parkinson’s disease (PD) can be viewed as a prototypical disorder of “brain arrhythmias”. Therefore, the modulation of relevant ion channels…Secondary Vascular Parkinsonism: Role of increasing levels cortisol in the cognitive impairment
Objective: Elevated cortisol levels are found in many diseases, including infectious, related to aging, depression, and associated with a depressive status. Elevated cortisol levels are…Apomorphine as a Diagnostic tool to Identify Levodopa Responsive Atypical Parkinsonism
Objective: To assess the efficacy of apomorphine in identification of levodopa responsive atypical parkinsonism. Background: Management of atypical parkinsonism is a challenge. Most of these…Clinical outcome of 6-pyruvoyl-tetrahydropterin synthase deficiency (PTPSd)
Objective: To assess morbility and clinical outcome of patients affected by defect of tetrahydrobiopterin (BH4) synthesis due to PTPSd. Background: PTPSd is a treatable genetic disorder…
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