Microstructural changes in GBA mutation carriers with depression
Objective: To investigate structural changes associated with depression in glucocerebrosidase (GBA) mutation carriers. Background: Depression is a common non-motor symptom in Parkinson’s disease (PD); however,…Wearable sensor monitoring in denovo Parkinson’s disease using the Parkinson’s KinetiGraph: pilot data and correlations from the MoNS-PD cohort
Objective: To describe Parkinson’s kinetograph utilised clinical parameters and correlations in a denovo Parkison’s disease (PD) cohort from Moscow Russia. Background: The Parkinson’s KinetiGraph™ (PKG)…Effect of regular practice of yoga versus aerobic exercise on motor and non motor signs and motor cortex plasticity in Parkinson’s disease
Objective: To test whether the regular practice of yoga (1) improves motor and non-motor symptoms and signs in Parkinson’s disease (PD) more than aerobic training…Apathy as a non-motor symptom(NMS) in patients with Parkinson’s disease(PwPD) and patients with Huntington’s disease(PwHD) in Tomsk, Russia
Objective: The aim is to evaluate and compare the apathy profile in PwHD and PwPD, using the same clinical criteria to assess the severity of…Unmet psychological needs of People with Parkinson’s disease
Objective: To investigate whether Parkinson’s disease (PD) specialists are identifying patients with Parkinson’s psychological needs and referring them to appropriate services. Background: A number of…Spreading ɑ-synuclein pathology initiated from the sublaterodorsal tegmental nucleus models RBD followed by Parkinsonian phenotypes in mice
Objective: To recapitulate ɑ-synucleinopathy based RBD-like behaviors in mice which could further proceed to develop Parkinsonian behavioral and histopathological phenotypes. Background: Idiopathic REM sleep behavior…Effect of Levodopa-Carbidopa Intestinal Gel Versus Optimized Medical Treatment on Dyskinesia in Advanced Parkinson’s Disease Patients: Final Results of the Randomized 12-Week DYSCOVER Study
Objective: This study evaluated the effectiveness of LCIG versus optimized medical treatment (OMT) on the duration and severity of dyskinesia in aPD patients. Background: Approximately…Blood-Brain Barrier Opening with Focused Ultrasound in Parkinson´s Disease with Cognitive Impairment: A Safety and Feasibility Study
Objective: To evaluate the safety and feasibility of MR guided focused ultrasound (MRgFUS) blood-brain barrier (BBB) opening in the cortex or the striatum in Parkinson´s…Serious games home rehabilitation program to treat gait and balance disorders in patients with Parkinson’s disease: A randomised controlled trial
Objective: To test the efficacy of an exergame rehabilitation programme at home to treat dopa-resistant gait and balance disorders in Parkinson’s disease (PD) patients. Background:…Deep Brain Stimulation impact on Social and Occupational Function in Parkinson’s Disease with Early Motor Complications
Objective: To investigate the effect of DBS compared with BMT on social, psychosocial and occupational functioning in PD patients ≤ 60 years of age with…
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