The induction of mitochondrial damage by alpha synuclein In Parkinson’s disease.
Objective: Alpha synuclein aggregation have been indicted in the process of neuronal cell loss in Parkinson's disease; however, there have been several hypothesis to explain…Efficacy and safety of adjunctive oral therapy in Parkinson’s disease with motor complications: a systematic review and network meta-analysis
Objective: To review the evidence and compare the efficacy and safety of catechol-O-methyltransferase inhibitors (COMT-Is), dopamine agonists (DAs) and monoamine-oxidase B inhibitors (MAOB-Is) as adjunctive…Microstructural abnormalities of the dentato-rubro thalamo-cortical tract in tremor dominant PD and ET plus syndrome: A DTI, NODDI and free water-based analysis
Objective: To evaluate microstructural integrity of the dentato-rubro thalamo-cortical tract (DRTT) in tremor dominant Parkinson’s disease (TDPD) and ET plus (ETP) syndrome using a multimodal…Disease progression of data-driven subtypes of Parkinson Disease (PD): 5-year longitudinal study from The Early Parkinson’s disease Longitudinal Singapore (PALS) cohort
Objective: To evaluate the non-motor symptom(NMS), motor and cognition progression among the Parkinson Disease (PD) clusters derived from data-driven approach. Background: Data-driven PD subtypes were…Disruption of Locus Coeruleus-Related Functional Networks in Parkinson’s Disease
Objective: We used resting-state functional MRI (rs-fMRI) to investigate the alterations of functional connectivity (FC) of LC-related resting-state networks (RSNs) and the associations between RSNs…Serum Zinc Deficiency could be associated with dementia conversion in Parkinson’s disease
Objective: To investigate the role of depletion or excess of various heavy metals on clinical characteristics of Parkinson's disease (PD) developing PD dementia in drug-naïve…Quantifying the value of multimodal MRI in outcomes prediction for STN DBS in PD
Objective: To compare the predictive value for motor outcomes of multimodal MRI to clinical predictors alone in STN DBS for PD. Background: STN DBS is…Investigating glutamate toxicity associated to Park2 mutations in pre-clinical models of Parkinson’s Disease
Objective: To generate and characterize induced pluripotent stem cells (iPSCs)-derived in vitro cellular models of Autosomal Recessive Juvenile Parkinsonism (ARJP) carrying Park2 mutations with a…Beyond Parkinson´s disease and synucleinopathies: unexpected identification of prodromal corticobasal syndrome by the updated MDS research criteria for prodromal PD
Objective: The aim of the current study was to determine the proportion of patients, initially classified as having prodromal Parkinson’s disease (pPD), phenoconverted to manifest…Referral patterns from primary care physicians to specialists among people with Parkinson’s disease or a Parkinson’s disease–related disorder
Objective: To evaluate referral patterns to a specialist by a primary care provider (PCP) or other healthcare provider (HCP) among people diagnosed with Parkinson’s disease…
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