Understanding the relationship between synaptic density and dopamine transporter availability in Parkinson’s disease
Objective: To evaluate how disease duration in PD affects the coupling of DAT (18F-FE-PE2I) and SV2A density (11C-UCB-J) in the nigrostriatal regions (where both tracers…Assessing the potential association of rs2298383 in ADORA2A as a predictor of Levodopa-Induced Dyskinesia in Latin American Parkinson’s Disease patients
Objective: To analyze the association between ADORA2A-rs2298383 and levodopa induced dyskinesias (LID) in a cohort of Latin American Parkinson’s disease patients. Background: Previous evidence has…Insights into Genetic Counseling Recall and Clinical Trial Interest in PD GENEration
Objective: To assess the impact of participation in PD GENEration, a large-scale genetic and counseling study for Parkinson’s disease (PD). We evaluated the recall of…Linking Adolescent Brain Development To Parkinson’s Disease Risk Using Machine Learning On Polygenic Risk Scores
Objective: Examine whether adolescent brain structural deviations contribute to Parkinson’s disease (PD) susceptibility. Background: Genetic variants associated with PD have been linked to neurodevelopmental processes,…Assessing Individual Risk Through Determination of Local Ancestry: Insights from the Global Parkinson’s Genetics Program
Objective: We're developing a scalable pipeline to infer local ancestry (LA) for individuals in the Global Parkinson's Genetics Program (GP2). This approach aims to enhance…Screening for GBA1 p.K198E PD-Risk Variant in Latin America
Objective: We aimed to assess the distribution of the GBA1 p.K198E variant, linked to Gaucher’s disease (GD) and increased Parkinson’s disease (PD) risk, across Latin…DBS Programming in Early Simultaneous STN-GPi Implantation for Young-Onset Parkinson’s: A Mini Case Series
Objective: We aim to present our institution's experience with simultaneous dual STN-GPi implantation in Parkinson’s disease (PD) by analyzing a case series of 3 patients.…Impact of Insurance and Risk Factors on DBS Outcomes
Objective: Assess the effect of insurance type on deep brain stimulation (DBS) outcomes, and identify risk factors for progression to assisted ambulation and dependency (home…Pallidotomy Reborn? Revisiting GPi Lesions in the Era of Neuro modulation for Parkinson’s Disease
Objective: To compare motor outcomes, surgical considerations, and follow-up data between unilateral GPi-DBS and GPi-RF pallidotomy in Parkinson’s disease (PD), evaluating their long-term efficacy and…Vitamin D3 Supplementation Ameliorates Non-Motor Symptoms Associated with Parkinson’s Diseases in a Rotenone Model in Wistar Rats
Objective: This study investigated the role of VD3 supplementation on non-motor symptoms and its mechanism of action in a rotenone rat model of PD. Background:…
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