Trihexyphenidyl as a Treatment for Severe Freezing of Gait in Parkinson’s Disease: A Case Report
Objective: To present a unique case in which trihexyphenidyl was used as an effective treatment to dramatically reduce freezing of gait (FoG) in a Parkinson’s…Zonisamide for Motor Symptoms and OFF-Time Reduction in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Objective: To evaluate the efficacy and safety of zonisamide as an adjunct therapy for improving motor function and reducing OFF-time in patients with Parkinson’s disease…Efficacy and Safety of Nicotine in Parkinson’s Disease: A Systematic Review and Meta-analysis
Objective: This systematic review and meta-analysis aimed to evaluate the safety and efficacy of nicotine compared with placebo in the treatment of Parkinson’s disease (PD).…The sphingolipid Lyso-Gb3, a biomarker for the lysosomal storage disorder Fabry Disease, is significantly elevated in blood from patients with Parkinson’s Disease
Objective: To better understand lysosomal dysfunction in Parkinson’s Disease. Background: Lysosomal dysfunction and α-synuclein accumulation play central roles in Parkinson’s Disease. They are interconnected by…Metabolomic breath landscape analysis unravels lipid biomarker candidates in patients with monogenic and idiopathic Parkinson’s disease
Objective: We propose an untargeted metabolomics approach using exhaled breath analysis to (1) characterize the non-volatile metabolomic breath signature of Parkinson’s disease (PD) patients with…Blood and CSF Biomarkers of Cognitive Impairment in Alpha Synucleinopathies
Objective: The aim was to investigate the role of both well-established and novel protein biomarkers of cognitive impairment in Parkinson’s disease (PD) and multiple system…Analyzing Longitudinal Correlation Between CSF Tau, Alpha-Synuclein, and Dysautonomia in Parkinson’s Disease Over Five Years
Objective: To examine the longitudinal association between tau, alpha-synuclein, and dysautonomia in Parkinson’s disease (PD). Background: PD is characterized by dopaminergic neural loss [1] and…Plasma Lipids as Potential Biomarkers for Progression of Sleep Disturbances in Parkinson’s Disease
Objective: Determine if plasma lipid levels can serve as a surrogate biomarker of future onset of RBD symptoms or nighttime sleep burden in patients with…Auditory Musical Hallucinations in Parkinson’s disease: A Case Series
Objective: To report a series of twelve patients with Parkinson’s disease (PD) who experienced auditory musical hallucinations (AMH). Background: Hallucinations occur in 20-40% of patients…Exploring Uncertainties and Fears of People with Parkinson Disease
Objective: To assess the burden of uncertainties, hopes, and fears of people with Parkinson disease (PwP). Background: Parkinson disease (PD) is associated with significant psychosocial…
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