Quality of Life of Parkinson’s Disease Patients in the Thai Population: A Cross-Sectional Analysis
Objective: Primary: To assess QoL in PD patients at the Neurological Institute of Thailand (NIT).Secondary: To identify clinical factors associated with QoL. Background: Parkinson’s disease…Negative Correlation between Apathy and Executive Functioning in Patients with Idiopathic Parkinson’s Disease without Dementia.
Objective: To establish the impact of apathy on executive functioning in patients with IPDWD. Background: Executive Functioning is one of the domains of neurocognitive functioning…Modeling Inflammation in GBA-Associated Parkinson’s Disease: Insights into Disease Mechanisms
Objective: This investigation centers on the role of inflammation in GBA-associated Parkinson’s disease (PD), a neurodegenerative disorder characterized by the progressive degeneration of dopaminergic neurons,…Cell-type specific bidirectional modulation of STN neurons rescue Parkinsonian motor symptom.
Objective: This study aimed to identify the specific STN cell type and circuit responsible for alleviating parkinsonian motor symptoms through targeted neural modulation. Background: The…Mass spectrometry-based screening for α-synuclein bioactive marine natural products
Objective: This study identifies marine-derived natural products with binding affinity and aggregation-inhibition activity against α-synuclein (α-syn) using a mass spectrometry (MS)-based screening approach. The objective…Characterising Peripheral Innate Immune Cell Infiltration into the Brain in Parkinson’s Disease
Objective: To characterise the infiltration of peripheral innate immune cells (NK cells, monocytes and neutrophils) into the brain in Parkinson’s disease (PD) and to investigate…Dopaminergic and Synaptic Alterations in SWEDD: Insights from [¹⁸F] FE-PE2I and [¹¹C] UCB-J PET Imaging
Objective: To investigate dopaminergic and synaptic density in SWEDD patients compared to idiopathic Parkinson’s disease (IPD) and healthy controls (HCs). Background: Scans Without Evidence of…Evaluation of swallow tail sign on 1.5 Tesla Magnetic Resonance Imaging in Parkinson´s disease patients in a tertiary hospital
Objective: To evaluate the swallow tail sign in 1.5 Tesla magnetic resonance imaging (MRI) scans of patients diagnosed with Parkinson's disease (PD). Background: Nigrosome-1 appears…Mining Metabolomics GWAS for Key Parkinson’s Disease Variants: A Bioinformatics Approach to Genetic-Metabolic Associations
Objective: To propose a novel approach to explore genetic-metabolic interactions in Parkinson’s disease (PD) by integrating the largest genome-wide association studies (GWASs) for PD and…Inflammatory profile in LRRK2-associated prodromal and clinical PD:a cross-sectional study
Objective: To investigate the peripheral inflammatory cytokine levels and their associations with clinical severity, dopaminergic presynaptic degeneration in asymptomatic carriers and PD patients with LRRK2 mutation.To investigate…
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