Identification of Metabolomic & Proteomic Panels for Parkinson’s Disease progression Diagnosis
Objective: Identify proteomic and metabolomic biomarkers for Parkinson’s Disease (PD) progression diagnosis using statistical and machine learning (ML) approaches, leveraging data from cerebrospinal fluid (CSF)…Reduced plasma levels of small HDL subfractions in advanced Parkinson’s disease
Objective: The present study investigated alterations of circulatory lipoprotein profiles, including cholesterol, triglycerides (TGs), phospholipids (PLs) and apolipoproteins (Apo) in lipoprotein subfractions, in Parkinson's disease…Plasma Biomarkers Predict Clinical Outcomes in Individuals with Neuronal α-Synuclein Disease and Amyloid-β Co-Pathology
Objective: We examined whether the plasma biomarkers pTau181, pTau217, GFAP, NfL, and Aβ42/40 are associated with cognitive, functional, and motor outcomes in individuals with neuronal…Classification of Medication State in Parkinson’s Disease Patients with and without Fluctuations using Facial Videos
Objective: This study presents a unique, interpretable Dual-Stream Transformer model for classifying medication state in patients with Parkinson’s disease (PD) using facial videos. Background: Recent…Enhancing Step Detection in Real-World Gait
Objective: To enhance accuracy and applicability of algorithms for step detection obtained from free-living gait accelerometer data in individuals with Parkinson’s Disease (PD). Background: When…A Qualitative Approach to Extract Diagnostic Patterns of Cognitive Impairment in Parkinson’s Disease
Objective: This study distilled patterns of patient performance recognized by clinical professionals in people with Parkinson’s disease (PD) and cognitive impairment on the Montreal Cognitive…Aberrations in Voluntary Thought Initiation: Parallels to Motor Freezing in Basal Ganglia Dysfunction
Objective: To explore the neurophysiological basis of impaired volitional thought initiation focusing on dorsal caudate dysfunction, aberrant pallidal-thalamic inhibition, and impaired corticostriatal integration. Background: While…Cerebral Vasoreactivity and Neuropsychiatric Features in Parkinson’s disease.
Objective: To determine cerebral vasoreactivity (CVR) in Parkinson’s disease (PD) and its association with the neuropsychiatric features of the disease. Background: Non-motor symptoms in PD…Orthostatic Hypotension and Acute Cognitive Dysfunction in Parkinson’s Disease: Insights from fNIRS
Objective: To define cerebral oxygenation changes during positional cognitive testing in Parkinson’s disease (PD), comparing those with orthostatic hypotension (OH+) to those without (OH-). Background:…Impact of Genetically Defined Ancestry on Progression of Idiopathic Parkinson’s Disease.
Objective: To assess the impact of genetically defined ancestry on progression of idiopathic Parkinson's Disease and evaluate the contribution of known genetic variation on any…
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