Oscillatory activity of pause-burst STN neurons shows an association with motor symptoms of Parkinson’s disease
Objective: Here we aimed to investigate heterogeneity in the neuronal activity within the subthalamic nucleus (STN) to search the association between oscillatory activity and motor…Assessment of microstructural changes associated with levodopa-induced dyskinesia in hemiparkinsonian rodents
Objective: To assess white matter (WM) microstructural integrity changes in pre-clinical models of Parkinson’s disease (PD) with levodopa-induced dyskinesia (LID). Background: PD is a neurodegenerative…Investigating the use of DAT-SPECT as an enrichment biomarker to determine eligibility for the phase 2 clinical trial PASADENA
Objective: Evaluate dopaminergic imaging DAT-SPECT as an enrichment strategy to avoid inclusion of participants with scans without evidence of dopaminergic deficit (SWEDD) in a Phase…Long-term follow-up of subthalamic nucleus deep brain stimulation for Parkinson’s disease: survival and disability milestones
Objective: To characterize retrospectively the long-term survival of 109 PD patients after 8 years of STN-DBS and to identify the incidence of the milestones of…Cortical beta activity in doorway-provoked motor blocks in Parkinson’s disease
Objective: To investigate cortical activity of doorway-provoked motor blocks (MB) during pedalling in Parkinson’s disease (PD). Background: Freezing of gait (FOG) is common in PD…Motor-Related and Cognition-Related Safety of Pimavanserin in Patients with Parkinson’s Disease Psychosis (PDP)
Objective: Evaluate motor- and cognition-related safety in pimavanserin-treated patients with PDP. Background: Pimavanserin, a selective 5-HT2A inverse agonist/antagonist, is the only US FDA-approved treatment for…Chronotype and Cognition in Veterans with Parkinson’s Disease
Objective: To determine if chronotype impacts the expression of dementia and/or depression in Veterans with Parkinson's disease (PD). Background: Chronotype reflects the periodicity of biological…Use of virtual reality devices for the monitoring of Parkinson’s disease
Objective: To determine whether mass market virtual reality (VR) devices can be used to detect the motor manifestations of Parkinson’s disease and their response to…Preliminary Verification of a Kinect-based System for Evaluating Postural Abnormalities in Patients with Parkinson’s Disease
Objective: In this study, we initially tested the reliability and validity of a Kinect-based system developed by our team with a cohort of small sample…The frequency of glucocerebrosidase mutations in a subgroup of early-onset Parkinson’s disease patients in the Korean population
Objective: We investigated the frequency of GBA mutations in the Korean patients with early-onset Parkinson’s disease (PD). Background: Glucocerebrosidase (GBA) mutations are associated with increased…
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