Proactive Brain Health Alliance Serving Those at Risk for Neurodegenerative Disease
Objective: Research advancements enable earlier identification of neurodegenerative disease risk via prodromal symptoms and genetic and biomarker testing. Those in the “space between” risk and…Paeoniflorin Combined with Neural Stem Cell Transplantation for Parkinson’s Disease: Synergistic Effects of Cell Therapy and Inflammation Regulation
Objective: To investigate the feasibility and efficacy of paeoniflorin (PF) combined with neural stem cell (NSC) transplantation in treating Parkinson's disease (PD). Background: Parkinson's disease…Clinical Characteristics and Biomarkers in Parkinson’s Disease Patients with Body-first versus Brain-first Subtypes in Parkinson’s Disease
Objective: To investigate clinical characteristics, disease progression, potential plasma and imaging biomarkers of body-first and brain-first Parkinson’s disease (PD) subtypes. Background: PD can be classified…Gait Analysis in Parkinson’s Disease with Mixed Reality
Objective: This study aims to analyze gait differences between individuals with Parkinson’s disease (PD) and healthy participants using the Timed Up-and-Go (TUG) test, exploring the…Digital Health Interventions for Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Objective: To assess the effectiveness of digital health interventions (DHIs) in patients with Parkinson's disease (PD) and report on their reach, uptake, and feasibility. Background:…The MJFF PRKN/PINK1 Project
Objective: To i) establish an expert consortium on PRKN/PINK1-linked Parkinson’s disease (PD), ii) improve our understanding of genotype-phenotype relationships and disease mechanisms, and iii) establish…Transcranial direct current stimulation combined with motor training for motor symptoms in Parkinson’s disease: a systematic review and meta-analysis
Objective: We aimed to compare the acute and retention effects of motor training alone versus its combination with transcranial direct current stimulation (tDCS) on motor…Results From a Dose-Blinded, Phase II Extension Study Evaluating Long-Term Efficacy, Safety and Tolerability of Minzasolmin in Participants With Parkinson’s Disease
Objective: ORCHESTRA XT (PD0055; NCT05543252) was a Phase II, dose-blinded extension of the ORCHESTRA Phase II, proof-of-concept study (NCT04658186). ORCHESTRA XT assessed the pharmacodynamic effects of…Efficacy of Combined Transcranial Direct Current Stimulation (tDCS) and Gait Training on Gait in Parkinson’s Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Objective: To evaluate the effects of addition of tDCS to gait training on gait parameters and motor function in individuals with Parkinson’s disease Background: Gait…Physiological assessment of swallowing related muscles in patients with Parkinson’s disease: characteristics and utility of high-density surface electromyography
Objective: The study focused on high-density surface electromyography (HD-sEMG) as a novel method to understand the electrophysiological characteristics of swallowing-related muscles in patients with Parkinson's…
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