Scans Without Evidence of Dopamine Deficiency (SWEDD) in Early-Onset Parkinson’s Disease: Comprehensive Clinical Analysis
Objective: Aim of this study is to comprehensively compare motor and non-motor symptoms of individuals with Early Onset Parkinson's Disease (EOPD) with dopamine deficiency to…Using Multi-Generational High-Risk Pedigrees to Identify Candidate Parkinson’s Disease Predisposition Genes
Objective: To identify rare genetic variants associated with increased risk of Parkinson’s disease (PD) in multi-generational, high-risk pedigrees. Background: Our current knowledge of PD genetics…Mutations of the VPS13A gene in a patient with Early-Onset Parkinson’s Disease: A case report.
Objective: To describe the case of a patient with early-onset Parkinson's Disease (PD) with variants of the VPS13A gene. Background: The vacuolar protein sorting 13A…European-Derived Parkinson’s Disease Polygenic Risk Score Model Is Associated With PD Status, UPDRS Score But Not Age At Onset Or Cognitive Impairment In An Egyptian PD Dataset
Objective: To assess the predictive ability of European-derived PD PRS model of 90 risk SNPs identified from the largest PD GWAS[1]in Egyptians and study its…Genome-wide Association Analyses Reveal Susceptibility Variants Linked to Parkinson’s Disease in the South African Population Using Inferred Global and Local Ancestry
Objective: The study aimed to investigate genetic risk factors for Parkinson’s disease (PD) in an admixed South African cohort using GWAS and local ancestry (LA)-GWAS…A Pan-Indian Genome-Wide Association Study of Parkinson’s Disease
Objective: To conduct the first pan-Indian genomic survey of PD across18 centres in India which included 4806 cases and 6363 controls. Background: The genetic architecture…Motor Outcomes Following Subthalamic Nucleus or Globus Pallidus Interna Deep Brain Stimulation in Early-Onset Parkinson’s Disease
Objective: Comparative outcomes between deep brain stimulation (DBS) targets in Early-onset Parkinson’s Disease (EOPD) patients are lacking. This study leverages the University of Florida’s (UF)…Are There Differences in Non-Motor Outcomes of Parkinson’s Disease Treated with GPi vs. STN Deep Brain Stimulation?
Objective: To evaluate the short-term effects of deep brain stimulation (DBS) of the Globus Pallidus internus (GPi) versus the Subthalamic Nucleus (STN) on non-motor symptoms,…Tracking The Role Of The Subthalamo-Temporal Network In Speech: A Deep Brain Stimulation-Electroencephalography Study
Objective: To identify deep brain stimulation (DBS)-related disruption of the subthalamic nucleus (STN)–temporal network as a possible source of STN-DBS induced dysarthria. Background: STN-DBS often…Analgesic Effect of Cannabidiol and Tetrahydrocannabinol(THC) on Pain Sensitivity in Reserpine Model of Parkinson’s Disease
Objective: The objectives of the study were to determine the effect of THC and CBD on:1. Thermal nociceptive threshold in reserpine induced Parkinson’s disease2. Mechanical…
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