Repeated Scanning Ultrasound in an Alpha-synuclein Preformed Fibril model
Objective: To investigate the therapeutic potential of repeated scanning ultrasound (SUS)-mediated blood-brain barrier (BBB) opening in a mouse model of Parkinson’s disease (PD). Background: PD…Theta burst transcranial ultrasound stimulation of internal globus pallidus and motor cortex in Parkinson’s disease
Objective: To compared the effects of theta burst transcranial ultrasound stimulation (tbTUS) applied to M1, the GPi, and simultaneous M1 and GPi stimulation to investigate…The Effect of Melatonin on Sleep Quality and Daytime Sleepiness in Parkinson’s Disease: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials
Objective: This study aims to systematically quantify the impact of melatonin on sleep quality and daytime sleepiness in individuals diagnosed with Parkinson’s disease (PD). Background:…Subdomain-specific cognitive decline and its effect on caregiver burden in Mexican population living with Parkinson’s Disease.
Objective: To determine whether different subdomains of the MoCA associate with caregiver burden. Background: Caregivers improve the quality of life for Parkinson's patients (PwP), despite…Qualitative research in advanced Parkinson’s disease: Exploring salient symptoms and suitability of the MDS-NMS from the patient, caregiver, and clinician perspective
Objective: To identify which non-motor symptoms (NMS) are most relevant in an advanced Parkinson’s Disease (PD) population and determine the suitability of the International Parkinson…Assessing Physiotherapy’s Role in Parkinson’s Disease Functionality in India: A Case Report
Objective: To find out the Assessing Physiotherapy's Role in Parkinson’s Disease Functionality in India: A Case Report Background: This case report explores the impact of…Wearable-based digital measures from the Verily Study Watch can detect concurrent symptomatic treatment effects in a subset of early-stage Parkinson’s disease ORCHESTRA trial participants
Objective: To investigate the effect of concurrent symptomatic treatment (ST) on digital measures collected in ORCHESTRA (NCT04658186). Background: Minzasolmin is an oral small molecule that…Proof-of-Concept Study Design Leveraging Digital Biomarkers to Enhance Statistical Power and Reduce Sample Size in PD Trials
Objective: Parkinson's disease clinical studies for disease modifying therapies face challenges of large sample size and long study duration due to subtle changes at early…A randomised controlled feasibility study of a technology-assisted home-based aerobic exercise program for individuals with Parkinson’s disease
Objective: The study evaluates the effectiveness of Combat PD, a mobile app designed to remotely deliver and monitor gamified aerobic exercise in promoting adherence and…A Phase II Randomized, Parallel, Double-blind, Placebo-controlled Study of the Efficacy and Safety of WD-1603 in Subjects with Parkinson’s Disease
Objective: To investigate the effectiveness, safety and pharmacokinetics of WD-1603 carbidopa-levodopa controlled-release tablets in subjects with Parkinson's disease. Background: The development of drug products that…
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