16-years of Evaluations for Prodromal Parkinson Features in an At-Risk Cohort with Gaucher Disease
Objective: To evaluate prodromal features of Parkinson disease in a cohort of "at-risk" Gaucher patients and GBA1 carriers . Background: Variants in GBA1 mutations are…VPS13C: a Modifier Gene causing Suboptimal Response to Levodopa in Early-Onset Parkinson’s Disease
Objective: To describe a retrospective clinical study of four cases carrying heterozygous pathogenic variants in the VPS13C gene with a clinical diagnosis of Early-Onset Parkinson’s…The Global Parkinson’s Genetics Program: Expanding the Diversity of Neurological Disorder Data: 2025 Update
Objective: To broaden the available data for Parkinson's Disease (PD) and related disorders by integrating genetic data from more than 115,000 participants worldwide through genotyping…CAP-003, a CNS-targeted IV-delivered AAV Gene Therapy Developed for Patients with Parkinson’s Disease associated with GBA1 Mutations
Objective: CAP-003 is a next-generation gene therapy candidate, comprising a novel brain-tropic capsid paired with hGBA1 cargo, that was developed for administration as a single…Electrophysiological Mapping in Asleep vs. Awake DBS
Objective: We report our experience using microelectrode recording (MER) in asleep vs. awake patients for DBS targeting Background: MER has played a crucial role in…Predictors of Clinical Benefit from Adaptive DBS Compared to Conventional DBS in Parkinson’s Disease
Objective: To identify patient characteristics predicting adaptive deep brain stimulation (aDBS) superiority over conventional DBS (cDBS) in Parkinson's disease (PD). Background: Adaptive DBS, modulated in…Rescue GPi DBS for Severe Dyskinesias and Dystonia in Long-Term STN DBS Parkinson’s Patients: A Case Series
Objective: Evaluate GPi DBS as a rescue therapy for refractory dyskinesias and dystonia in long-term STN DBS patients. Background: STN DBS effectively reduces medication dependency…Prevalence of Supine Hypertension in Alpha-Synucleinopathies: a Systematic Review and Meta-Analysis
Objective: We aimed to conduct a systematic review and meta-analysis to assess the prevalence of supine hypertension (SH) in α-synucleinopathies. Background: Alpha-synucleinopathies, including Parkinson’s Disease…Impact of Sleep Disturbance and Early Morning OFF Symptoms on Health-Related Quality of Life in Advanced Parkinson’s Disease
Objective: To quantify the impact of sleep disturbance (Sd) and early morning OFF (EMO) symptoms on health-related quality of life (HRQoL) in people with advanced…Correlation between Orthostatic Hypotension and Cognitive Impairment in Parkinson’s Disease
Objective: This study aims to investigate the relationship between OH and cognitive impairment in PD patients using gray matter volume (GMV) analysis. Background: Orthostatic hypotension…
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