Uncovering the mechanisms of genotype by environment interaction in an idiopathic Parkinson’s disease model in Drosophila
Objective: To identify the genetic basis and the molecular mechanisms that underlie the susceptibility of developing motor defects in response to exposure to pesticides in…Curcumin prevented electrophysiological and behavioral alterations in a rotenone model of Parkinson’s disease
Objective: This study discusses the in vivo electrophysiology of the hippocampus, behavioral correlates after rotenone intoxication. Background: Parkinson's disease is a progressive nervous system disorder…Evaluation of the anxiolytic effects of naringenin in rotenone-induced rat model of Parkinson’s disease by an elevated plus maze test
Objective: The study was designed to assess the anxiolytic effects of naringenin on rotenone-induced anxiety-like behavior, biochemical and neurochemical alterations. Background: Anxiety is a preclinical…Neuroprotective effects of allicin microemulsion against intrastriatal rotenone and manganese induced Parkinsonism in rats
Objective: Allicin is flavonoid that possess neuroprotective potential but main impediment is its low bioavailability which was improved with microemulsion. The present study was framed…Sex-specific neuroprotection by inhibition of the Y-chromosome gene, SRY, in experimental Parkinson’s disease
Objective: Given the presence and function of SRY in male DA (dopamine) neurons, we hypothesised that dysregulation of SRY may contribute to male susceptibility to…Rotenone exposure is associated with mitochondrial DNA (mtDNA) damage in humans
Objective: To determine if mtDNA damage can serve as a biomarker of prior pesticide exposure. Background: Mitochondrial dysfunction is a hallmark of PD, and exposure…Poly-ADP-ribose polymerase 1 modulates mitochondrial fission via LRRK2 in a rotenone-induced Parkinson’s disease model
Objective: To clarity the effects and mechanism of poly-ADP-ribose polymerase 1(PARP1) in regulating mitochondrial fusion/fission in a rotenone-induced Parkinson's disease (PD) model. Background: Accumulating evidences…The role of lipid metabolism in mouse models of Parkinson’s disease
Objective: To investigate the role of lipid metabolism and the effect of blocking carnitine palmitoyl-transferase 1 (CPT1) in toxic and genetically mouse models of Parkinson’s…The Role of Environmental Toxins (Rotenone) in Parkinson’s Disease
Objective: Learn the role of environmental toxins - rotenone in development of Parkinson's disease Background: Rotenone is a powerful pesticide. It is also a lipophilic…Exposed-Only Analysis of Gene-Pesticide Interaction in Parkinson’s Disease (PD)
Objective: Assess gene-pesticide associations with PD using an exposed-only design in a highly exposed cohort. Background: Pesticide use is associated with an increased risk of…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.