GPR30 agonists attenuate haloperidol-induced neurotoxicity in SH-SY5Y cells and adult zebrafish.
Objective: Objective:1. To investigate the neuroprotective effect of FDA-approved compounds (Raloxifene and Fulvestrant) against haloperidol-induced neurotoxicity in SHSY-5Y cells and adult zebrafish2. To explore the molecular…Effects of ectopic dopamine D2 autoregulation of raphe-striatal projecting neurons on established L-DOPA-mediated behaviors in a hemiparkinsonian rat model
Objective: Levodopa (LD) is the standard treatment for Parkinson’s Disease (PD) despite risk of LD-induced dyskinesia (LID) development within a decade of treatment. Serotonergic (5-HT)…Higher Putamen Volume Asymmetry with Age-Preserved Volume in Isolated Adult-Onset Cervical Dystonia
Objective: This study aims to explore the relationship between left and right putamen volumes in cervical dystonia (CD) patients compared to age-matched healthy controls (HC),…The clinical features, neuroimagings and outcomes of diabetic striatopathy: a retrospective study at tertiary hospital in Vietnam
Objective: This study aims to analyze the clinical features, neuroimaging findings, and outcomes of diabetic striatopathy among Vietnamese patients. Background: Diabetic striatopathy (DS) is a…Diabetic striatopathy with stroke – like symptoms: A case report
Objective: To describe a rare case of diabetic striatopathy in a woman with type 2 diabetes mellitus presenting with unilateral hemichorea, dysarthria and left hemiparesis…Understanding diffusion in extracellular space in synucleinopathy
Objective: To understand the extracellular space (ECS) diffusion in synucleinopathy. Background: The pathogenic mechanisms underlying synucleinopathies involve the spread and propagation of α-synuclein aggregates throughout…A Post-mortem Study on Striatal Glia and Blood Brain Barrier Integrity in Aging and PD Asian-Indians.
Objective: We examined the glial and blood brain barrier (BBB) changes related to normal aging and PD in the Asian-Indian striatum. Background: increases the risk…AAV5-miHTT gene therapy mediates sustained mutant huntingtin lowering in brain and cerebrospinal fluid of Huntington’s disease minipigs up to 5 years
Objective: Our objective is to assess long-term safety of and durability of an adeno-associated viral vector serotype 5 encoding an engineered miRNA (AAV5-miHTT) targeting human…Dopamine depletion of striatal subregions and motor dysfunction in prodromal and clinical Parkinson’s disease
Objective: This aim of this study was to investigate how dopamine depletion of different striatal subregions contributes to motor symptoms in patients with prodromal and…Evoking Parkinsonism in Mice by a Pharmacological Approach Combined with Targeted Viral-based Manipulations of Neuronal Ensembles
Objective: We implement a pharmacological approach for eliciting dopamine deprivation using transient blockage of dopamine signaling to replicate core parkinsonian motor symptoms. Background: Parkinson’s disease…
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