Pharmacokinetics And Safety Of YA-101, A Dual Inhibitors Of D-Amino Acid Oxidase (DAAO) And NLRP3 Inflammasome, In Healthy Subjects: A Double-Blind, Placebo-Controlled, Randomized, Single Dose and Multiple Dose Phase I Study
Objective: To evaluate the safety, tolerability, and pharmacokinetics (PK) profile of YA-101 in healthy volunteers with single dose and multiple dose Background: Multiple System Atrophy…Explore cellular heterogeneities of orbitofrontal cortex in multiple system atrophy using spatial transcriptomics
Objective: To explore the spatial organization and cellular complexity of the orbitofrontal cortex (OFC) in multiple system atrophy (MSA) via spatial transcriptomic (SRT). Background: The…Seed Amplification Assay for the differentiation of αSyn seed subtypes
Objective: To identify soluble αSyn-seed types present in brain homogenate (BH) and CSF using αSyn seed amplification assay (synSAA) Background: Lewy bodies and neurites are…Increasing diagnostic accuracy of Multiple System Atrophy – A Videolibrary on clinical and imaging features
Objective: To provide short, high-quality videos and MRI images presenting typical MSA features to supplement new MDS-MSA criteria1. Background: The MDS criteria for the diagnosis…Rapid Cognitive Deterioration and Related Factors in Progressive Supranuclear Palsy: a One-Year Follow-up Study
Objective: Based on a relatively large cohort, we aimed to show the switch of cognitive status in patients with progressive supranuclear palsy (PSP) after one-year follow-up…Altered activity of lysosomal hydrolases in monocyte-derived macrophages as potential biomarker for differential diagnosis of multiple system atrophy
Objective: The aim was to assess the possibility of differentiating synucleinopathies (Parkinson’s disease (PD), dementia with Lewy bodies (DLB), multiple system atrophy (MSA) by lysosomal…Serotonin Transporter Dynamics in Multiple System Atrophy: Insights from 123I-FP-CIT SPECT Imaging
Objective: We aimed to visualize a serotonin transporter (SERT) based on 123I-FP-CIT SPECT, and assessing the binding distribution characteristics of the brainstems between patients with…Clinical and neuroimaging factors associated with survival in Multiple System Atrophy
Objective: To assess clinical and neuroimaging factors associated with survival in a cohort of patients with a final clinical diagnosis of Multiple System Atrophy (MSA)…Role of the Alpha-synuclein Seed Amplification Assay in Parkinson’s Disease Clinical Trials: A Case Report of Multiple System Atrophy Misdiagnosed as Parkinson’s Disease
Objective: Report a patient with Multiple System Atrophy (MSA) misdiagnosed as Parkinson’s disease (PD) and enrolled in a clinical trial for PD treatment with Mesenchymal…Video-oculography for enhancing the diagnostic accuracy of early oculomotor dysfunction in Progressive Supranuclear Palsy
Objective: To test (1) the role of video oculography (VOG) in the detection of slow saccades in two common subtypes of Progressive Supranuclear Palsy (PSP)…
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