Brain perfusion patterns associated with motor symptoms in multiple system atrophy
Objective: There is a need for objective methods to assess disease progression in multiple system atrophy (MSA). This study aimed to identify brain perfusion patterns…Neuroprotective efficacy of EDTA against manganese neurotoxicity: Implications for modulating Parkinsonian syndromes
Objective: This study investigates the neuroprotective potential of ethylenediaminetetraacetic acid (EDTA) in reducing the neurotoxic effects of manganese (Mn), focusing on both motor and non-motor…Exploring the Role of Aperiodic and Periodic Spectral Activity in Guiding Deep Brain Stimulation Electrode Selection for Childhood Dystonia
Objective: To evaluate the potential of aperiodic and periodic neural activity in guiding clinical deep brain stimulation (DBS) programming for children with dystonia. Background: DBS…Advancing Hypomimia Assessment in Parkinson’s Disease by Integrating a Continuous Monitoring Device into Clinical Practice
Objective: We aim to establish a robust, continuous method for monitoring hypomimia in Parkinson’s disease (PD), bridging the gap between sporadic clinical evaluations and real-life…Efficacy and Safety of Ecopipam for Tourette Syndrome (TS): Results From a Phase 3, Randomized, Double-Blind, Placebo-Controlled Withdrawal Trial
Objective: To evaluate the efficacy and safety of ecopipam, a dopamine D1 receptor antagonist, as a maintenance therapy in children, adolescents, and adults with TS.…Real-World Adverse Event Profile in Children and Adolescents With Tourette Syndrome Treated With Dopamine D2 Receptor Antagonists (D2RAs) Compared With Non-D2RAs
Objective: To further explore the safety profile of dopamine D2 receptor antagonists (D2RAs) for Tourette syndrome (TS) in a community setting. Background: D2RAs (aripiprazole/haloperidol/pimozide) are…Novel Multiple System Atrophy Subtypes Identified Using Unsupervised Machine Learning Algorithms
Objective: To identify a novel disease subtype of multiple system atrophy (MSA) by applying machine learning algorithms to a large cohort of autopsy-confirmed MSA. Background:…Exploring The Correlation of Neuroimaging, Molecular and Electrophysiological Biomarkers in Patients with Progressive Supranuclear Palsy – Richardson Type
Objective: To correlate blood and electrophysiological biomarkers in Progressive Supranuclear Palsy – Richardson’s type (PSP-RS) patients with brain structural alterations using neuromorphometry. Background: Various biomarkers, including…Machine Learning Analysis of DTI-Derived Free Water Reveals Distinct Parkinson’s Disease Subtypes: A Two-Year Longitudinal Study
Objective: To identify distinct subtypes of Parkinson’s disease (PD) based on diffusion tensor imaging (DTI)-derived free water (FW) patterns in basal ganglia (BG) structures using…Paroxysmal Nonkinesigenic Dyskinesia in GLUT1 Deficiency Syndrome: A Rare Manifestation
Objective: We describe a rare case of paroxysmal nonkinesigenic dyskinesia (PKND) in a patient with GLUT1 deficiency syndrome (GLUT1-DS). Background: Various movement disorders are a…
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