Neuroprotection of indole-derivative compound NC001-8 in Parkinson disease cell model by regulatory of NRF2 pathway
Objective: The goal of this study is to investigate the effects of indole-derivative compound NC001-8 on neuroprotection in PD disease cell model. Background: Parkinson’s disease…Physical and cognitive stimulation through environmental enrichment prevents early molecular pathology in a Parkinson´s disease model
Objective: Understand the molecular principles and identify genetic drivers underlying and mitigating the preventative effects of environmental enrichment on the unfolding of Parkinson´s disease (PD) pathology.…The therapeutic effect of MANF in the MPTP/MPP+-induced model of Parkinson’s disease
Objective: To observe therapeutic effect of MANF in the attenuation of neurotoxin MPTP/MPP+-induced model of Parkinson's disease Background: Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a…Genetic analysis of RAB39B mutations in early-onset and familial Parkinson’s Disease in a Taiwanese population.
Objective: To examine the genetic contribution of RAB39B to early-onset and familial PD in a Taiwanese population. Background: Loss of function mutations in RAB39B were…Alteration of early endosomal trafficking causes neurodegeneration in PARK20
Objective: To elucidate the molecular basis of the Park20 by evaluating the role of synaptojanin 1 in intracellular trafficking. Background: Recently a new form of…Progression to Parkinson’s disease in carriers of LRRK2 G2019S mutation: a 4-year prospective study with serial dopamine transporter imaging
Objective: To assess whether any of the biomarkers studied (UPDRS-III, SN echogenicity, UPSIT and DaT-SPECT) in a baseline evaluation of a cohort of LRRK2 G2019S asymptomatic…Parkin (PARK 2) Mutations in Patients with Early-Onset Parkinson’s Disease
Objective: Genetic testing Parkin (PARK 2) gene in patients with young-onset Parkinson's disease in Belarus. Background: The diagnosis of young-onset Parkinson's disease (PD) is the same…Screening of GBA and LRRK2 G2019S Mutations in Egyptian Parkinson’s Disease Patients
Objective: We aim to estimate the frequency of mutations in the glucocerebrosidase gene (GBA) and LRRK2 G2019S in a yet unstudied Egyptian Parkinson's disease population from the…Rare variant analysis of the PPMI dataset to uncover the complex genetic architecture of Parkinson’s disease
Objective: To unravel the genetic factors that play a role in PD we used the whole exome sequencing data available as a part of Parkinson…Interest in Genetic Testing in Parkinson’s disease patients with DBS
Objective: To determine interest in genetic testing among Parkinson’s disease (PD) patients with deep brain stimulation (DBS). Background: Nearly 27% of patients with early-onset PD…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.