A Visual Interpretation Algorithm for Assessing 18F-Florzolotau PET Scans in Progressive Supranuclear Palsy
Objective: This study aimed to develop a visual reading algorithm dedicated to the evaluation of 18F-Florzolotau positron emission tomography (PET) scans in PSP. Background: The…Genetic signatures stratify PwP into three subgroups with differing responses in two disease-modifying Phase 3 trials and indicate multiple disease biology pathways to Parkinson’s Disease
Objective: To evaluate if 3 newfound genetic subgroups represent differing aspects of disease biology in PD by determining if subgroup participants have differing responses to…Development of an AAV-mediated artificial miRNA targeting human alpha-synuclein (α-syn) as a potential gene therapy for Synucleinopathies
Objective: To develop an adeno-associated virus (AAV)-based artificial miRNA (miRNA) system targeting human α-syn. Background: Synucleinopathies such as Parkinson’s disease (PD) and Multiple System Atrophy…A Curious Case of Copper de-Compensation
Objective: To describe the investigation and management of a patient with Wilson’s disease who experienced late-onset neurological deterioration despite continued treatment. Background: Wilson’s disease is…Differentiating Progressive Supranuclear Palsy from Corticobasal Syndrome Using Cortical Diffusion MRI
Objective: To compare cortical microstructural measures in Progressive Supranuclear Palsy (PSP) and Corticobasal Syndrome (CBS) using cortical diffusion magnetic resonance imaging (MRI). Background: Differential diagnosis…Rationale for LRRK2 inhibition in sporadic Parkinson’s disease and the LUMA trial
Objective: To summarize the rationale for LRRK2 inhibition in sporadic PD patients without LRRK2 mutations, and to describe the current design of the LUMA study,…Neuroimaging Factors Differentially Associated with Pathology and Clinical Presentation
Objective: Examine utility of a factor analysis approach to neuroimaging data in Lewy body disease (LBD) and Alzheimer’s disease (AD). Background: Significant heterogeneity exists among patients…Association of Retinol Binding Protein (RBP) and the Risk of Parkinson’s disease (PD): A Narrative Literature Review
Objective: This review aimed to investigate the association between RBP levels and the risk of Parkinson’s disease Background: RBP facilitates retinol transport from the liver…IGF2 Induce Neuroprotection in PD Preclinical Models by Modulation of Immune Response.
Objective: We propose to determine a therapeutic strategy based on adoptive transfer of macrophages reprogrammed for recombinant IGF2 (rIGF2) treatment in PD preclinical model. Background:…Structural magnetic resonance imaging patterns reflect α-synuclein propagation in a model of Parkinson’s Disease
Objective: To evaluate structural magnetic resonance imaging (MRI) pattern modifications in an α-synuclein model of Parkinson’s disease (PD). Background: As an early driver of α-synucleinopathies’…
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