A Phase II Randomized, Parallel, Double-blind, Placebo-controlled Study of the Efficacy and Safety of WD-1603 in Subjects with Parkinson’s Disease
Objective: To investigate the effectiveness, safety and pharmacokinetics of WD-1603 carbidopa-levodopa controlled-release tablets in subjects with Parkinson's disease. Background: The development of drug products that…Proof-of-Concept Study Design Leveraging Digital Biomarkers to Enhance Statistical Power and Reduce Sample Size in PD Trials
Objective: Parkinson's disease clinical studies for disease modifying therapies face challenges of large sample size and long study duration due to subtle changes at early…Efficacy of ND0612 in Patients at Different Stages of Disease Severity: Subgroup-Analyses From a Randomized, Active-Controlled Study in People With Parkinson’s Disease Experiencing Motor Fluctuations
Objective: To evaluate the efficacy of investigational ND0612 in reducing motor fluctuations in patients with Parkinson’s disease (PD) at different stages of disease and/or symptom…LRRK2 Pathway Inhibition By NEU-411, a Potent, Selective, CNS-Penetrant LRRK2 Inhibitor In Healthy Participants
Objective: The aim of this work was to evaluate LRRK2 pathway modulation by the potent, selective, CNS-penetrant LRRK2 inhibitor NEU-411 in healthy adults and elderly…Efficacy and Safety of Different Apomorphine Formulations for OFF Episodes in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Objective: To assess the efficacy and safety of different apomorphine formulations for managing OFF episodes in Parkinson’s disease (PD) through a systematic review and meta-analysis.…Trends on recruitment and retention in Parkinson’s Disease modification trials
Objective: To identify the most common causes of participant’s screen failure (SF) and drop-out (DO) in Phase 2 and 3 Disease Modification Therapy (DMT) trials…Independent and Synergistic Effects of Subthalamic Temporal Interference Stimulation on Motor Symptoms in Parkinson’s Disease
Objective: To evaluate the independent effects of subthalamic transcranial temporal interference stimulation (tTIS) on motor symptoms in Parkinson’s Disease (PD) and to assess its…Retro walking: A Potential Indicator of Physical Frailty in Parkinson’s Disease.
Objective: To examine the associations between retro walking and frailty parameters such as low grip strength, exhaustion, low physical activity and weight loss and compare…Quality of Life Improvements in Parkinson’s Disease for Those Treated with Photobiomodulation Plus Exercise: A Sham-Controlled Study
Objective: To assess whether exercise alone, or exercise combined with photobiomodulation (PBM) can improve the health-related quality of life (QoL) for people with Parkinson’s disease…Multipronged, Community-Engaged Approach to Recruiting Lewy Body Dementia Family Caregivers for a National Trial
Objective: Describe a three-tiered initiative to recruit Lewy Body Dementia (LBD) family caregivers into a national randomized controlled trial (PERSEVERE, NCT06389032). Background: LBD is often…
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