Continuous subcutaneous delivery of solubilized carbidopa improves the pharmacokinetic profile of levodopa
Objective: To characterize the peripheral pharmacokinetics and CNS metabolism of levodopa during continuous subcutaneous delivery of solubilized carbidopa. Background: Although many commercial levodopa formulations include…Association of Parkinson’s disease with essential tremor
Objective: In this study we present the clinical characteristics of 10 patients (6 males, 4 females) with both essential tremor (ET) and Parkinson's disease (PD).…Can treadmill training facilitate the dual-task gait in Parkinson’s disease?
Objective: Investigate the effects of a single session of treadmill gait training combined with cognitive tasks on dual-task gait in Parkinson's disease. Background: The loss…The potential therapeutic effect of intranasal administration of stem cells in rotenone model of Parkinson’s disease in mice
Objective: In this study we assessed the potential beneficial effect of intranasal administration of mesenchymal stem cells (MSCs) to rotenone model of PD in C57bl/6…ND0701: A novel safe concentrated apomorphine formulation for continuous subcutaneous administration via a patch pump
Objective: To characterize the local safety and PK of a novel apomorphine formulation, ND0701, in comparison to a commercially available apomorphine–HCl solution. Background: Apomorphine is…Osteopathic manipulative treatment in Parkinson’s disease: Preliminary results of a double blind sham-controlled cross-over study
Objective: The primary objective of this study is to quantitatively evaluate the effect of osteopathic manipulative treatment (OMT) in Parkinson's disease. Background: Patients with Parkinson's…Use of nicotine gum to treat acute low blood pressure in Parkinson’s disease
Objective: To evaluate (1) how nicotine chewing gum is tolerated (2) how nicotine chewing gum affects acute low blood pressure (BP) in Parkinson's disease (PD).…Motor fluctuations in relation to plasma concentrations following a single-dose of levodopa/carbidopa microtablets in advanced Parkinson’s disease
Objective: The aim of this study was to characterize the levodopa and carbidopa plasma concentration in relation to blinded motor function ratings. This is a…Levodopa-carbidopa intestinal gel in routine care of advanced Parkinson’s disease patients: Final long-term efficacy results on motor complications from the GLORIA registry
Objective: To evaluate the effect of levodopa-carbidopa intestinal gel (LCIG, designated in the United States as carbidopa-levodopa enteral suspension) on motor fluctuations and dyskinesia in…The NIC-PD-study –Baseline data of a randomized, placebo-controlled, double-blind, multi-centre trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson’s disease in Germany and the USA
Objective: The primary endpoint of clinical progression is measured by change in the total UPDRS score between baseline and 1) after 52 weeks of study…
Abstracts from the International Congress of Parkinson’s and Movement Disorders.