Plasma tau-species-containing neuron-derived extracellular vesicles as potential biomarkers for progressive supranuclear palsy
Objective: This study aimed to develop and validate novel plasma PSP biomarkers based on tau-species-containing neuron-derived extracellular vesicles (NDEVs) in two independent cohorts (discovery and…Clinical Features Suggestive of Alpha-Synucleinopathy in Progressive Supranuclear Palsy
Objective: To compare the presence of symptoms suggestive of synucleinopathy between PSP-parkinsonism (PSP-P), Parkinson's disease (PD) and PSP-Richardson syndrome (PSP-RS). Background: Clinical signs with high…Unraveling the Genetic Architecture of Progressive Supranuclear Palsy in East Asians
Objective: We aim to elucidate the genetic architecture of progressive supranuclear palsy (PSP) in East Asians through whole-exome sequencing in a multi-center study in Taiwan.…Unveiling a rare case: Novel TBK1 variant presenting as Multiple system atrophy-like phenotype
Objective: Tumour necrosis factor NF-ƘB activator (TANK) binding kinase 1 (TBK1) is necessary for immune and inflammatory responses. Reports of TBK1 with neurodegeneration are noted…Oxidative stress in Progressive Supranuclear Palsy
Objective: The goal of the study is to evaluate the significance of oxidative stress in the examination and pathophysiology of Progressive Supranuclear Palsy (PSP). Additionally,…Characterizing the Patient Clinical Journey Before and After Diagnosis of Friedreich Ataxia and Differences by Age at Diagnosis
Objective: To characterize the patient journey through clinical specialties involved in the intermediate-to-late age at diagnosis of adult patients with Friedreich ataxia (FA) based on…Clinical Deficits, Quality of Life and Caregiver Burden across PSP Phenotypes
Objective: To assess clinical deficits, quality of life and caregiver burden across progressive supranuclear palsy (PSP) phenotypes considering also other variables such as age, sex…Atypical Parkinsonian Syndromes Presenting with Homonymous Hemianopsia
Objective: We present here two cases of atypical parkinsonism with visual field loss to help increase recognition and drive research efforts forward to elucidate the…Alpha-Synuclein Promotes the Expression and Release of Neurofilament Light Chain from Oligodendrocytes in Multiple System Atrophy
Objective: This study aims to determine the Neurofilament light chain (NfL) expression in oligodendrocytes, investigate whether excess α-synuclein (α-syn) impacts NfL expression, release, and functions…Metabolic Patterns in Multiple System Atrophy: Brain Network Insights from Spatial ICA of FDG-PET
Objective: This study employs spatial independent component analysis (ICA) on 18F-fluorodeoxyglucose (FDG)-PET imaging to decompose metabolic heterogeneity in Multiple system atrophy (MSA), identifying key brain…
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