Analysis of the Association between SNCA Polymorphisms and the Risk of Multiple System Atrophy
Objective: To assess the impact of twenty-one single nucleotide polymorphisms (SNPs) located in different regulatory regions of the SNCA gene on the risk of developing…Connectome of Pathology Stages of Progressive Supranuclear Palsy
Objective: Find the relations between normative FC and seed-to-seed correlations in pathological tau load. Model the FC maps for twelve patients, using post-mortem tau pathology…Safety, Tolerability and Pharmacokinetics of a Novel Oral OGA Inhibitor (FNP-223) First-in-Human Phase 1 Study
Objective: To evaluate the safety, tolerability, and pharmacokinetics of FNP-223 (formerly ASN90) in healthy volunteers (HV). Background: Proteinopathies remain largely untreatable and novel therapies are…Clinical and Genetic spectrum of Developmental dyskinetic encephalopathy – Experience from a Tertiary care centre
Objective: To provide unique data on the clinical and genetic spectrum of developmental dyskinetic encephalopathies. Background: Developmental dyskinetic encephalopathy(DDE) is a recently described clinically and…Expanding the Spectrum of Alzheimer’s Disease Clinical Presentations: Progressive Dysarthria with Monomelic Tremor
Objective: To present an unusual clinical presentation of an atypical Corticobasilar syndrome secondary to Alzheimer's disease. Background: Corticobasilar syndrome (CBS) typically presents with motor symptoms…Noradrenaline treatment of apathy and impulsivity in participants with Progressive Supranuclear Palsy syndromes (NORAPS)
Objective: The NORAPS phase II study (ISRCTN99462035) investigates the safety, tolerability and efficacy of atomoxetine in Progressive Supranuclear Palsy (PSP). Background: PSP is a neurodegenerative…Incorporating Patient and Care Partner Feedback on the Protocol for a Clinical Trial Assessing Progression in MSA
Objective: Describe the perspectives of people living with MSA (PwMSA) and their care partners on the design and operational characteristics of a phase 3 trial…Neurogenic bladder and affective disorders in parkinsonism
Objective: To determine the relationship between psychoemotional and dysuria dysfunctions in patients with PD and MSA. Background: In the group of patients with extrapyramidal pathology…White Matter Abnormalities in Progressive Supranuclear Palsy (PSP) vs. Parkinson’s Disease (PD): Evaluation with a Convolutional Neural Network (CNN)-Based Tool
Objective: This study aimed to compare white matter hyperintensity (WMH) burden between PSP and PD using a novel AI-based tool for more accurate WMH volume…Functional Alterations in Early-Stage Parkinson’s Disease and Multiple System Atrophy with REM Sleep Behavior Disorder
Objective: This study investigated functional brain network alterations in early-stage Parkinson’s disease (PD) and multiple system atrophy (MSA) patients with probable rapid eye movement sleep…
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