The Clinical Implication of Dysphagia in Patients with Multiple System Atrophy
Objective: This study aimed to explore the correlation between dysphagia and key clinical features in Multiple System Atrophy (MSA) patients, along with investigating the link…Seed Amplification Assay for the differentiation of αSyn seed subtypes
Objective: To identify soluble αSyn-seed types present in brain homogenate (BH) and CSF using αSyn seed amplification assay (synSAA) Background: Lewy bodies and neurites are…Optical Coherence Tomography Findings in Multiple System Atrophy: Insights into Disease Subtypes, Clinical Correlations, and Dopaminergic Degeneration
Objective: This study aimed to evaluate optical coherence tomography (OCT) findings in multiple system atrophy (MSA) patients, with a focus on disease subtypes, clinical correlations,…Is cathepsin D a good target for therapy in Tau-related conditions?
Objective: To study the involvement of cathepsin D in the pathogenesis of Tau-related conditions. Background: The endo-lysosomal system (ELS) is central in processing of neurodegenerative…Unsupervised Learning Approach for Pathology-Based Subtyping and Staging Multiple System Atrophy
Objective: To develop a classification and staging system for multiple system atrophy (MSA) using data-driven disease progression modeling. Background: MSA exhibits varying degrees of degeneration…Heterogeneity of multiple system atrophy with an analysis of the clinical case
Objective: Multiple system atrophy (MSA) is a rapidly progressive neurodegenerative disease clinically characterized by various combinations of Parkinsonism with resistance to levodopa, cerebellar, autonomic, and…Association Between Clinical Progression in Multiple System Atrophy and Brain Volume Changes Evaluated via Deep Learning Segmentation
Objective: Assess brain volume changes in patients with multiple system atrophy (MSA) over one year. Background: Identifying disease progression biomarkers is crucial for advancing MSA…Familial Multiple System Atrophy-Mimics: Importance of Comprehensive Evaluation
Objective: We present two patients initially diagnosed as familial MSA until one of the patients was proven to be metachromatic leukodystrophy (MLD). Background: Multiple system…Serotonin Transporter Dynamics in Multiple System Atrophy: Insights from 123I-FP-CIT SPECT Imaging
Objective: We aimed to visualize a serotonin transporter (SERT) based on 123I-FP-CIT SPECT, and assessing the binding distribution characteristics of the brainstems between patients with…Role of the Alpha-synuclein Seed Amplification Assay in Parkinson’s Disease Clinical Trials: A Case Report of Multiple System Atrophy Misdiagnosed as Parkinson’s Disease
Objective: Report a patient with Multiple System Atrophy (MSA) misdiagnosed as Parkinson’s disease (PD) and enrolled in a clinical trial for PD treatment with Mesenchymal…
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