Role of presenilin 1 variants in parkinsonism
Objective: To characterize presenilin 1 gene (PSEN1) variants which can cause parkinsonism. Background: Variants in PSEN1 are associated with early onset Alzheimer’s disease mainly due…Machine Learning Model using Eye Movements for the Differential Diagnosis of iPD and Atypical Parkinsonian Syndromes
Objective: To develop a machine learning (ML) model to first between differentiate between healthy controls, idiopathic PD, Atypical Parkinsonian syndromes and then further subclassify as…Improving Automatic Speech Recognition for Speakers with Parkinson’s disease
Objective: 1. Obtain high-fidelity, speech data from 400 people with Parkinson’s (PWP) to train automatic speech recognition (ASR) systems.2. Develop and implement procedures to recruit,…A Longitudinal Quantitative Assessment of Phosphorylated Alpha-Synuclein Deposition in Dementia with Lewy Bodies
Objective: To report the quantitative change in cutaneous phosphorylated alpha-synuclein (P-SYN) deposition over time in patients with dementia with Lewy bodies (DLB) in a longitudinal…Mechanical Peripheral Stimulation for the Treatment of Gait Disorders in Patients with Parkinson’s Disease (GONDOPARK): A Multi-centre, Double-blind, Crossover Randomized Controlled Trial
Objective: The interventional clinical study GONDOPARK aims at evaluating the effects of AMPS treatment on gait speed and gait-related disorders in subjects with PD.The interventional…Dopamine-Responsive Post-Anoxic Parkinsonism
Objective: To describe a retrospective case series of five cases of dopamine-responsive post-anoxic parkinsonism. Background: Parkinsonism following hypoxic ischemic damage of the basal ganglia is…Parkinsonism following Chronic Disulfiram Overdose
Objective: To describe the effect of chronic intake of disulfiram Background: Background- Drug induced parkinsonism is one of the commonest causes of non-degenerative parkinsonism. Typical…Using large language models to assess dynamics in semantic memory search of patients with Parkinson’s disease
Objective: This study aimed to investigate dynamics in the semantic memory searching process of Parkinson’s disease patients. Background: Linguistic studies in Parkinson’s disease highlighted the…Seed amplification assay detects alpha-synuclein in cerebrospinal fluid in pre- and symptomatic autosomal dominant Alzheimer’s disease
Objective: To examine the ability to detect concurrent Lewy Body Disease via Lew Body pathology (LBP) in Autosomal Dominant Alzheimer’s Disease (ADAD) through detection of…Investigating the Role of Age and Neurological Status on Adaptive Balance Strategies: A Systematic Review Utilizing Big Data Techniques
Objective: To examine the influence of age and neurological status on adaptive balance strategies using big data analytics and systematic review methodologies. Background: Balance control…
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